ArticleProceedings of the National Academy of Sciences of the United States of America2018
Pathological transitions in myelin membranes driven by environmental and multiple sclerosis conditions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Adsorption of Myelin Basic Protein on Model Myelin Membranes Reveals Weakening of van der Waals Interactions in a Lipid Ratio-Dependent Manner.Membranes · 2025Article
- Prolonged Visual Evoked Potential Latencies in Dogs Naturally Infected with Canine Distemper Virus.Viruses · 2024Article
- A multiscale tissue assessment in a rat model of mild traumatic brain injury.Journal of neuropathology and experimental neurology · 2022Article
- The Lung Microbiome: A Potential Target in Regulating Autoimmune Inflammation of the Brain.Neuroscience bulletin · 2022Article
- Non-Specific Low Back Pain, Dietary Salt Intake, and Posterior Lumbar Subcutaneous Edema.International journal of environmental research and public health · 2022Article
- Multiple sclerosis projection in Tehran, Iran using Bayesian structural time series.BMC neurology · 2021Article
- Nile Red fluorescence spectroscopy reports early physicochemical changes in myelin with high sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein.Frontiers in chemistry · 2021Article
- Inhibition of neutral sphingomyelinase 2 promotes remyelination.Science advances · 2020Article
- The Role of Vesicle Trafficking and Release in Oligodendrocyte Biology.Neurochemical research · 2020Review
- Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease.Cells · 2020Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is an autoimmune disease, leading to the destruction of the myelin sheaths, the protective layers surrounding the axons. The etiology of the disease is unknown, although there are several postulated environmental factors that may contribute to it. Recently, myelin damage was correlated to structural phase transition from a healthy stack of lamellas to a diseased inverted hexagonal phase as a result of the altered lipid stoichiometry and low myelin basic protein (MBP) content. In this work, we show that environmental conditions, such as buffer salinity and temperature, induce the same pathological phase transition as in the case of the lipid composition in the absence of MBP. These phase transitions have different transition points, which depend on the lipid's compositions, and are ion specific. In extreme environmental conditions, we find an additional dense lamellar phase and that the native lipid composition results in similar pathology as the diseased composition. These findings demonstrate that several local environmental changes can trigger pathological structural changes. We postulate that these structural modifications result in myelin membrane vulnerability to the immune system attacks and thus can help explain MS etiology.
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