ArticleProceedings of the National Academy of Sciences of the United States of America2018
Color opponency with a single kind of bistable opsin in the zebrafish pineal organ.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 66 citations in OpenAlex.
- From pineal photoreception to optogenetics: functional colour opponency based on a pineal bistable opsin.Eye and vision (London, England) · 2026Review
- Neural circuits for decision-making based on pineal photoreception in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Pinopsin Regulates Melatonin Production and Daily Locomotor Activity: Functional Insights From Gene-Edited Xenopus Tadpoles.Journal of pineal research · 2026Article
- Optimized in vivo two-photon imaging reveals the essential role of the contralateral eye in functional optic nerve regeneration in zebrafish larvae.Eye and vision (London, England) · 2025Article
- Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin.iScience · 2025Article
- Dataset of cone opponent mechanisms and spectral tuning in non-primate vertebrates.Data in brief · 2024Article
- Functional characterization of four opsins and two G alpha subtypes co-expressed in the molluscan rhabdomeric photoreceptor.BMC biology · 2023Article
- Optogenetic manipulation of Gq- and Gi/o-coupled receptor signaling in neurons and heart muscle cells.eLife · 2023Article
- Recent advances in biological rhythm and non-visual photoreception: Report for the session 10 at the 19th International Conference on Retinal Proteins.Biophysics and physicobiology · 2023Article
- Multiple opsins in a reef-building coral, Acropora millepora.Scientific reports · 2023Article
- High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Expression of a homologue of a vertebrate non-visual opsin Opn3 in the insect photoreceptors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Insights into the evolutionary origin of the pineal color discrimination mechanism from the river lamprey.BMC biology · 2021Article
- Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons.EMBO reports · 2021Article
- Functional identification of an opsin kinase underlying inactivation of the pineal bistable opsin parapinopsin in zebrafish.Zoological letters · 2021Article
- Optogenetic Potentials of Diverse Animal Opsins: Parapinopsin, Peropsin, LWS Bistable Opsin.Advances in experimental medicine and biology · 2021Review
- Colored visual stimuli evoke spectrally tuned neuronal responses across the central nervous system of zebrafish larvae.BMC biology · 2020Article
- The non-visual opsins expressed in deep brain neurons projecting to the retina in lampreys.Scientific reports · 2020Article
- Lamprey Parapinopsin ("UVLamP"): a Bistable UV-Sensitive Optogenetic Switch for Ultrafast Control of GPCR Pathways.Chembiochem : a European journal of chemical biology · 2020Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lower vertebrate pineal organs discriminate UV and visible light. Such color discrimination is typically considered to arise from antagonism between two or more spectrally distinct opsins, as, e.g., human cone-based color vision relies on antagonistic relationships between signals produced by red-, green-, and blue-cone opsins. Photosensitive pineal organs contain a bistable opsin (parapinopsin) that forms a signaling-active photoproduct upon UV exposure that may itself be returned to the signaling-inactive "dark" state by longer-wavelength light. Here we show the spectrally distinct parapinopsin states (with antagonistic impacts on signaling) allow this opsin alone to provide the color sensitivity of this organ. By using calcium imaging, we show that single zebrafish pineal photoreceptors held under a background light show responses of opposite signs to UV and visible light. Both such responses are deficient in zebrafish lacking parapinopsin. Expressing a UV-sensitive cone opsin in place of parapinopsin recovers UV responses but not color opponency. Changes in the spectral composition of white light toward enhanced UV or visible wavelengths respectively increased vs. decreased calcium signal in parapinopsin-sufficient but not parapinopsin-deficient photoreceptors. These data reveal color opponency from a single kind of bistable opsin establishing an equilibrium-like mixture of the two states with different signaling abilities whose fractional concentrations are defined by the spectral composition of incident light. As vertebrate visual color opsins evolved from a bistable opsin, these findings suggest that color opponency involving a single kind of bistable opsin might have been a prototype of vertebrate color opponency.
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