ArticleProceedings of the National Academy of Sciences of the United States of America2018
Birth delivery mode alters perinatal cell death in the mouse brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Effect of cesarean section on the risk of autism spectrum disorders/attention deficit hyperactivity disorder in offspring: a meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Cesarean delivery on maternal request and common child health outcomes: A prospective cohort study in China.Journal of global health · 2022Trial
- Impact of Cesarean Delivery on Reward Behavior and Tyrosine Hydroxylase in the Nucleus Accumbens of Adult Prairie Vole Offspring.Developmental psychobiology · 2026Article
- Gut microbiome is associated with insula structure in neonates.Physiology & behavior · 2025Article
- Unravelling the Gut-Microbiome-Brain Axis: Implications for Infant Neurodevelopment and Future Therapeutics.Current microbiology · 2025Review
- Current status of fertility rates and modes of delivery after restorative proctocolectomy with ileal pouch-anal anastomosis.International journal of colorectal disease · 2025Article
- Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section.Scientific reports · 2024Article
- Impact of cesarean section on metabolic syndrome components in offspring rats.Pediatric research · 2024Article
- Delivery by cesarean section leads to heavier adult bodyweight in prairie voles (Microtus ochrogaster).Hormones and behavior · 2024Article
- The gut microbiota-immune-brain axis in a wild vertebrate: dynamic interactions and health impacts.Frontiers in microbiology · 2024Article
- The inflammatory response to birth requires MyD88 and is driven by both mother and offspring.Brain, behavior, and immunity · 2024Article
- Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally.Scientific reports · 2023Article
- Lasting consequences on physiology and social behavior following cesarean delivery in prairie voles.Hormones and behavior · 2023Article
- Brain effects of gestating germ-free persist in mouse neonates despite acquisition of a microbiota at birth.Frontiers in neuroscience · 2023Article
- Development of the infant gut microbiome predicts temperament across the first year of life.Development and psychopathology · 2022Article
- The immune cell profile of the developing rat brain.Brain, behavior, and immunity · 2022Article
- The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study.Cancer epidemiology · 2022Article
- Regional Differences in Gamma-Aminobutyric Acid and Glutamate Concentrations in the Healthy Newborn Brain.AJNR. American journal of neuroradiology · 2022Article
- Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy.NeuroImage · 2021Review
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5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Labor and a vaginal delivery trigger changes in peripheral organs that prepare the mammalian fetus to survive ex utero. Surprisingly little attention has been given to whether birth also influences the brain, and to how alterations in birth mode affect neonatal brain development. These are important questions, given the high rates of cesarean section (C-section) delivery worldwide, many of which are elective. We examined the effect of birth mode on neuronal cell death, a widespread developmental process that occurs primarily during the first postnatal week in mice. Timed-pregnant dams were randomly assigned to C-section deliveries that were yoked to vaginal births to carefully match gestation length and circadian time of parturition. Compared with rates of cell death just before birth, vaginally-born offspring had an abrupt, transient decrease in cell death in many brain regions, suggesting that a vaginal delivery is neuroprotective. In contrast, cell death was either unchanged or increased in C-section-born mice. Effects of delivery mode on cell death were greatest for the paraventricular nucleus of the hypothalamus (PVN), which is central to the stress response and brain-immune interactions. The greater cell death in the PVN of C-section-delivered newborns was associated with a reduction in the number of PVN neurons expressing vasopressin at weaning. C-section-delivered mice also showed altered vocalizations in a maternal separation test and greater body mass at weaning. Our results suggest that vaginal birth acutely impacts brain development, and that alterations in birth mode may have lasting consequences.
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