Evidence map›Paper›PMID 30322923›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

Kim Newton, Debra L Dugger, Arundhati Sengupta-Ghosh, Ronald E Ferrando, Felix Chu, Janet Tao, Wendy Lam, Susan Haller, Sara Chan, Susan Sa and 14 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  9. Impairment of DET1 causes neurological defects and lethality in mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  12. Review
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  19. Article
  20. Functional characterization of SOX2 as an anticancer target.Signal transduction and targeted therapy · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 1 institution in 1 country.

Kim NewtonDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080; knewton@gene.com dixit@gene.com.
Debra L DuggerDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080.
Arundhati Sengupta-GhoshDepartment of Neuroscience, Genentech, South San Francisco, CA 94080.
Ronald E FerrandoDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Felix ChuDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Janet TaoDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Wendy LamDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Susan HallerDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Sara ChanDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Susan SaDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Debra DunlapDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Jeffrey Eastham-AndersonDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Hai NguDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Jeffrey HungDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Dorothy M FrenchDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Joshua D WebsterDepartment of Pathology, Genentech, South San Francisco, CA 94080.
Brad BolonGEMpath, Longmont, CO 80504.
Jinfeng LiuDepartment of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080.
Rohit RejaDepartment of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080.
Sarah KummerfeldDepartment of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080.
Ying-Jiun ChenDepartment of Molecular Biology, Genentech, South San Francisco, CA 94080.
Zora ModrusanDepartment of Molecular Biology, Genentech, South San Francisco, CA 94080.
Joseph W LewcockDepartment of Neuroscience, Genentech, South San Francisco, CA 94080.
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA 94080; knewton@gene.com dixit@gene.com.
NewPath Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The E3 ubiquitin ligase CRL4

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBrainDNA-Binding ProteinsMaleMiceMice, Inbred C57BLNuclear ProteinsProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-junTranscription FactorsUbiquitinUbiquitin-Protein LigasesBasic Helix-Loop-Helix ProteinsCOP1 protein, mouseDNA-Binding ProteinsNuclear ProteinsProto-Oncogene Proteins c-etsProto-Oncogene Proteins c-junTranscription FactorsUbiquitinUbiquitin-Protein Ligasesc-JUNCOP1ETV1ETV4ETV5

Identifiers

PMID30322923
PMCPMC6217379
OpenAlexW2896376481

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.