ArticleThe EMBO journal2019
Loss of T-bet confers survival advantage to influenza-bacterial superinfection.
Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 26 citations in OpenAlex.
- Nebulized glycyrrhizin/enoxolone drug modulates IL-17A in COVID-19 patients: a randomized clinical trial.Frontiers in immunology · 2023Trial
- Using interpretable machine learning models to predict the occurrence of severe influenza in hospitalized children: a retrospective cohort study.BMC medical informatics and decision making · 2026Article
- T-cell immunity against influenza virus does not require Th1 or Th17 master regulator transcription factors.Mucosal immunology · 2025Article
- Preexisting vaccine-primed heterosubtypic T cell immunity protects the maternal-fetal unit from adverse influenza outcomes in mice.The Journal of clinical investigation · 2025Article
- Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity.Clinical and experimental immunology · 2024Review
- Review
- Hematopoietic stem and progenitor cells confer cross-protective trained immunity in mouse models.iScience · 2023Article
- Role of mitochondrial stress and the NLRP3 inflammasome in lung diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Microbial and Immune Regulation of the Gut-Lung Axis during Viral-Bacterial Coinfection.Journal of bacteriology · 2023Review
- Immune predisposition drives susceptibility to pneumococcal pneumonia after mild influenza A virus infection in mice.Frontiers in immunology · 2023Article
- Regulation of CD4 T Cell Responses by the Transcription Factor Eomesodermin.Biomolecules · 2022Review
- Bona Fide Th17 Cells without Th1 Functional Plasticity Protect against Influenza.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Microbial (co)infections: Powerful immune influencers.PLoS pathogens · 2022Review
- Interleukin-17-A multifaceted cytokine in viral infections.Journal of cellular physiology · 2021Review
- Dysregulation of Pulmonary Responses in Severe COVID-19.Viruses · 2021Article
- Influenza Infection Induces Alveolar Macrophage Dysfunction and Thereby Enables NoninvasiveJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Age-Associated B Cells (ABCs) in the Prognosis, Diagnosis and Therapy of Systemic Lupus Erythematosus (SLE).Mediterranean journal of rheumatology · 2020Review
- Mice Deficient in T-bet Form Inducible NO Synthase-Positive Granulomas That Fail to ConstrainJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming.Mucosal immunology · 2019Article
- Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor, T-bet, regulates type 1 inflammatory responses against a range of infections. Here, we demonstrate a previously unaddressed role of T-bet, to influenza virus and bacterial superinfection. Interestingly, we found that T-bet deficiency did not adversely affect the efficacy of viral clearance or recovery compared to wild-type hosts. Instead, increased infiltration of neutrophils and production of Th17 cytokines (IL-17 and IL-22), in lungs of influenza virus-infected T-bet
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.