Evidence map›Paper›PMID 30322883›Full record

ArticleThe Journal of general physiology2018

The S6 gate in regulatory Kv6 subunits restricts heteromeric K

Aditya Pisupati, Keith J Mickolajczyk, William Horton, Damian B van Rossum, Andriy Anishkin, Sree V Chintapalli, Xiaofan Li, Jose Chu-Luo, Gregory Busey, William O Hancock and 1 more

Abstract read
In one paragraph

Article in The Journal of general physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. A Historical Outline of Fluorescence Spectroscopy in Ion Channel Research.Advances in experimental medicine and biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. The Electrically Silent Kv5.1 Subunit Forms Heteromeric Kv2 Channels in Cortical Neurons and Confers Distinct Functional Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated KProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. Pentameric assembly of the Kv2.1 tetramerization domain.Acta crystallographica. Section D, Structural biology · 2022
    Article
  11. What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Aditya PisupatiDepartment of Biology, Pennsylvania State University, University Park, PA.ORCID 0000-0003-3105-0716
Keith J MickolajczykDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA.
William HortonDepartment of Animal Science, Pennsylvania State University, University Park, PA.ORCID 0000-0001-9717-0169
Damian B van RossumThe Jake Gittlen Laboratories for Cancer Research, College of Medicine, Pennsylvania State University, Hershey, PA.
Andriy AnishkinDepartment of Biology, University of Maryland, College Park, MD.ORCID 0000-0002-5877-1591
Sree V ChintapalliArkansas Children's Nutrition Center and Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR.
Xiaofan LiDepartment of Biology, Pennsylvania State University, University Park, PA.ORCID 0000-0002-9885-1289
Jose Chu-LuoDepartment of Biology, Pennsylvania State University, University Park, PA.
Gregory BuseyDepartment of Biology, Pennsylvania State University, University Park, PA.ORCID 0000-0002-4589-682X
William O HancockDepartment of Biomedical Engineering, Pennsylvania State University, University Park, PA.
Timothy JeglaDepartment of Biology, Pennsylvania State University, University Park, PA tjj3@psu.edu.ORCID 0000-0001-8616-2390

Funding

Molecular mechanism of kinesin motilityR01GM076476 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HANCOCK, WILLIAM OLAF · 2006 to 2019
$3.5M
Characterization of a novel animal model of epilepsy, the Kv12.2 -/- mouseR01NS069842 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI JEGLA, TIMOTHY J · 2010 to 2014
$1.7M
A biophysical approach to elucidating the molecular mechanisms of mitotic inhibitor targetsF99CA223018 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI MICKOLAJCZYK, KEITH JOSEPH · 2017 to 2017
$33k
NCI NIH HHS F99 CA223018NIGMS NIH HHS R01 GM076476NINDS NIH HHS R01 NS069842
6 · The paper itself

Abstract

The Shaker-like family of voltage-gated K

Indexed as

Models, MolecularAmino Acid SequenceAnimalsCadmiumMiceMicroscopy, FluorescenceOocytesPatch-Clamp TechniquesPotassium Channels, Voltage-GatedSea AnemonesXenopusCadmiumPotassium Channels, Voltage-Gated

Identifiers

PMID30322883
PMCPMC6279357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.