Evidence map›Paper›PMID 30322872›Full record

ArticleDisease models & mechanisms2018

Targeting ulcerative colitis by suppressing glucose uptake with ritonavir.

Henrika Jodeleit, Omar Al-Amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. NOD/Scid IL2RγJID innovations : skin science from molecules to population health · 2024
    Article
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  5. Article
  6. Review
  7. Article
  8. Frontiers in pharmacology · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Small-Molecule Inhibition of Glucose Transporters GLUT-1-4.Chembiochem : a European journal of chemical biology · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Henrika JodeleitDepartment of General-, Visceral-, Transplantation- and Vascular Surgery, University Hospital, LMU Munich, Nussbaumstr. 20, 80336 Munich, Germany.
Omar Al-AmodiDepartment of General-, Visceral-, Transplantation- and Vascular Surgery, University Hospital, LMU Munich, Nussbaumstr. 20, 80336 Munich, Germany.
Janina CaesarDepartment of General-, Visceral-, Transplantation- and Vascular Surgery, University Hospital, LMU Munich, Nussbaumstr. 20, 80336 Munich, Germany.
Christina Villarroel AguileraDepartment of General-, Visceral-, Transplantation- and Vascular Surgery, University Hospital, LMU Munich, Nussbaumstr. 20, 80336 Munich, Germany.
Lesca HoldtDepartment of Laboratory Medicine, Institute of Laboratory Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Roswitha GroppDepartment of General-, Visceral-, Transplantation- and Vascular Surgery, University Hospital, LMU Munich, Nussbaumstr. 20, 80336 Munich, Germany Roswitha.gropp@med.uni-muenchen.de.ORCID 0000-0003-4756-261X
Florian BeigelDepartment of Medicine II, University Hospital, LMU Munich, Marchioninistr. 15, 81377 München, Germany.
Matthias SiebeckDepartment of General-, Visceral-, Transplantation- and Vascular Surgery, University Hospital, LMU Munich, Nussbaumstr. 20, 80336 Munich, Germany.
LMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucose is the preferred source of energy in activated inflammatory cells. Glucose uptake into the cell is ensured by a family of glucose uptake transporters (GLUTs), which have been identified as off-target molecules of the HIV protease inhibitor ritonavir. In this study, we examined the effect of ritonavir on inflammation

Indexed as

AdultAged, 80 and overAnimalsAspartic AcidBiomarkersCD4-Positive T-LymphocytesColitis, UlcerativeDisease Models, AnimalFemaleGlucoseGlutamic AcidHumansInflammationLeukocytesMaleMiddle AgedAspartic AcidBiomarkersGlucoseGlutamic AcidRitonavirGlucose transporterInflammationMetabolic switchMouse modelNOD-scid IL-2RγnullRitonavirUlcerative colitis

Identifiers

PMID30322872
PMCPMC6262818
OpenAlexW2897519257

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.