Evidence map›Paper›PMID 30322864›Full record

ReviewThe Journal of experimental medicine2019

The gut microbiome: Relationships with disease and opportunities for therapy.

Juliana Durack, Susan V Lynch

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 520 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
520citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

520 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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460 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Juliana DurackDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA juliana.durack@ucsf.edu.ORCID 0000-0002-8916-9376
Susan V LynchDivision of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA susan.lynch@ucsf.edu.

Funding

Proteomic Predictors of Chronic Kidney Disease in Liver Transplant RecipientsR21AI113916 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEVITSKY, JOSH · 2014 to 2015
$428k
NIAID NIH HHS R21 AI113916
6 · The paper itself

Abstract

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions.

Indexed as

ImmunomodulationIntestinal MucosaAgingChronic DiseaseGastrointestinal MicrobiomeHumansInflammation

Identifiers

PMID30322864
PMCPMC6314516

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.