Evidence map›Paper›PMID 30322672›Full record

ArticleUltrasound in medicine & biology2019

Mitigation of Articular Cartilage Degeneration and Subchondral Bone Sclerosis in Osteoarthritis Progression Using Low-Intensity Ultrasound Stimulation.

Xiaofei Li, Yueli Sun, Zhilun Zhou, Dongye Zhang, Jian Jiao, Minyi Hu, Chaudhry Raza Hassan, Yi-Xian Qin

Abstract read
In one paragraph

Article in Ultrasound in medicine & biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. [Research progress of different mechanical stimulation regulating chondrocytes metabolism].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xiaofei LiDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Yueli SunDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Zhilun ZhouDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Dongye ZhangDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Jian JiaoDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Minyi HuDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Chaudhry Raza HassanDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
Yi-Xian QinDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA. Electronic address: yi-xian.qin@stonybrook.edu.
Stony Brook University · US

Funding

Functional Fluid Flow Regulated Bone RegenerationR01AR061821 · NIAMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI QIN, YI-XIAN · 2012 to 2016
$1.7M
Role of Musculo-Dynamics in Bone Fluid Flow, Circulation and AdaptationR01AR052379 · NIAMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI QIN, YI-XIAN · 2005 to 2009
$1.7M
NIAMS NIH HHS R01 AR052379NIAMS NIH HHS R01 AR061821
6 · The paper itself

Abstract

The purpose of this study was to evaluate the effect of low-intensity ultrasound on articular cartilage and subchondral bone alterations in joints under normal and functional disuse conditions during osteoarthritis (OA) progression. Total of thirty 5-mo-old female Sprague-Dawley rats were randomly assigned to six groups (n = 5/group): age-matched group, OA group, OA + ultrasound (US) group, hindlimb suspension (HLS) group, HLS + OA group and HLS + OA + US group. The surgical anterior cruciate ligament was used to induce OA in the right knee joints. After 2 wk of OA induction, low-intensity ultrasound generated with a 3-MHz transducer with 20% pulse duty cycle and 30 mW/cm

Indexed as

Ultrasonic WavesAnimalsCartilage, ArticularCartilage DiseasesDisease Models, AnimalFemaleOsteoarthritisRatsRats, Sprague-DawleySclerosisTibiaX-Ray MicrotomographyAcoustic radiation forceArticular cartilageJoint disuseLow-intensity ultrasoundOsteoarthritisSubchondral bone

Identifiers

PMID30322672
PMCPMC6289639
OpenAlexW2896365664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.