Evidence map›Paper›PMID 30322482›Full record

ArticleAlcohol (Fayetteville, N.Y.)2018

Stress vulnerability and alcohol use and consequences: From human laboratory studies to clinical outcomes.

Vijay A Ramchandani, Bethany L Stangl, Sara K Blaine, Martin H Plawecki, Melanie L Schwandt, Laura E Kwako, Rajita Sinha, Melissa A Cyders, Sean O'Connor, Samir Zakhari

Abstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 47 citations in OpenAlex.

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  7. Low Psychological Resilience Predict the Risk for Alcohol Use Disorder in General Population: National Mental Health Survey of Korea 2021.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Vijay A RamchandaniSection on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States. Electronic address: vijayr@mail.nih.gov.
Bethany L StanglSection on Human Psychopharmacology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
Sara K BlaineDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Martin H PlaweckiIndiana University School of Medicine, Department of Psychiatry, Indianapolis, IN, United States.
Melanie L SchwandtOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
Laura E KwakoOffice of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, United States.
Rajita SinhaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Melissa A CydersPurdue University School of Science, Indianapolis, IN, United States.
Sean O'ConnorIndiana University School of Medicine, Department of Psychiatry, Indianapolis, IN, United States; R.L. Roudebush VA Medical Center, Indianapolis, IN, United States.
Samir ZakhariOffice of Science, Distilled Spirits Council of the United States, Washington, DC, United States.
National Institute on Alcohol Abuse and Alcoholism · USIndiana University – Purdue University Indianapolis · USYale University · USOffice of Science · USRichard L. Roudebush VA Medical Center · US

Funding

NIAAA Repository/Screening Database Management and ResearchZIAAA000130 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SCHWANDT, MELANIE · 2017 to 2025
$60.1M
Translational Research and Science Education (OUT)P60AA007611 · NIAAA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI DAVID A. KAREKEN · 2003 to 2026
$45.5M
Alcohol Pharmacokinetics and Pharmacodynamics in HumansZIAAA000466 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI RAMCHANDANI, VIJAY ARJUN · 2009 to 2025
$31.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Chronic Alcohol and Brain Stress Circuit ResponseR01AA013892 · NIAAA · YALE UNIVERSITY · PI Rajita Sinha · 2003 to 2026
$10.1M
Analysis: Emotion-Based Alcohol Consumption with fMRI and Experimental ParadigmK01AA020102 · NIAAA · INDIANA UNIVERSITY INDIANAPOLIS · PI CYDERS, MELISSA A · 2011 to 2015
$770k
Alcohol Pharmacokinetics and Pharmacodynamics in HumansZ01AA000466 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI RAMCHANDANI, VIJAY ARJUN · 2006 to 2008
$762k
Multimodal Neuroimaging of Alcohol Cues, Cortisol Response, and Compulsive MotivationK99AA025401 · NIAAA · YALE UNIVERSITY · PI BLAINE, SARA KEELAN · 2017 to 2018
$148k
Intramural NIH HHS Z01 AA000466NCATS NIH HHS UL1 TR001108NIAAA NIH HHS K01 AA020102NIAAA NIH HHS K99 AA025401NIAAA NIH HHS P60 AA007611NIAAA NIH HHS R01 AA013892NIAAA NIH HHS ZIA AA000466
6 · The paper itself

Abstract

It is well known that vulnerability to stress is a risk factor for alcohol use disorder (AUD). Chronic alcohol use can result in neuroadaptations in cortico-striatal pathways and hypothalamic pituitary adrenal (HPA) axis function that are manifested in altered behavioral and cognitive control functions contributing to alcohol craving, compulsive motivation, consumption, and consequences. This symposium brings together studies utilizing novel approaches to help improve our understanding of stress - past, acute, and chronic - on alcohol seeking and consumption and related outcomes using a combination of human laboratory models, neuroimaging, and clinical measures. Examining factors that determine vulnerability as well as resilience to stress are of particular interest in the study of AUD because, in addition to increasing our understanding of the risk factors for AUD, such knowledge can be used to develop more effective treatments. Dr. Stangl presented a novel human experimental model that demonstrates, for the first time, stress-induced increases in alcohol self-administration in binge drinkers using a guided imagery paradigm combined with intravenous alcohol self-administration (IV-ASA). Dr. Blaine presented data demonstrating that glucocorticoid response to stress drives compulsive alcohol motivation and intake in binge/heavy drinkers. Dr. Plawecki presented data examining sex differences in the effect of two distinct stress paradigms - mood induction and abstinence - on IV-ASA in moderate drinkers. Dr. Schwandt presented clinical data providing a new perspective on the relationship between childhood trauma and AUD by suggesting possible underlying mechanisms that confer resilience, rather than vulnerability, to severe early life stress exposure.

Indexed as

Administration, IntravenousAdult Survivors of Child AbuseAdverse Childhood ExperiencesAlcoholismBinge DrinkingCentral Nervous System DepressantsEthanolHumansHypothalamo-Hypophyseal SystemPersonalityPituitary-Adrenal SystemResilience, PsychologicalSelf AdministrationSex FactorsStress, PsychologicalCentral Nervous System DepressantsEthanolAlcohol use disorderEarly life stressfMRIGenderIntravenous alcohol self-administrationResilience

Identifiers

PMID30322482
PMCPMC6842306
OpenAlexW2805118586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.