ArticleeLife2018
Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Untargeted Blubber Metabolomics Reveals Biochemical Signatures Associated with Physiological Status in Live, Free-Ranging Bottlenose Dolphins.Metabolites · 2026Article
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner.Cell reports · 2024Article
- Article
- Protein succinylation, hepatic metabolism, and liver diseases.World journal of hepatology · 2024Review
- The Impact of Ketone Body Metabolism on Mitochondrial Function and Cardiovascular Diseases.Journal of atherosclerosis and thrombosis · 2023Review
- Diversified Mammalian Visuasl Adaptations to Bright- or Dim-Light Environments.Molecular biology and evolution · 2023Article
- Decay ofEcology and evolution · 2022Article
- Functional loss of ketogenesis in odontocete cetaceans.The Journal of experimental biology · 2021Article
- Dietary Diversification and Specialization in Neotropical Bats Facilitated by Early Molecular Evolution.Molecular biology and evolution · 2021Article
- Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos.Current biology : CB · 2021Article
- PseudoChecker: an integrated online platform for gene inactivation inference.Nucleic acids research · 2020Article
- A genome alignment of 120 mammals highlights ultraconserved element variability and placenta-associated enhancers.GigaScience · 2020Article
- Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations.Science advances · 2019Article
- The Singularity of Cetacea Behavior Parallels the Complete Inactivation of Melatonin Gene Modules.Genes · 2019Article
- The dopamine receptor DPeerJ · 2019Article
- Article
- Loss of Enzymes in the Bile Acid Synthesis Pathway Explains Differences in Bile Composition among Mammals.Genome biology and evolution · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Apart from glucose, fatty acid-derived ketone bodies provide metabolic energy for the brain during fasting and neonatal development. We investigated the evolution of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.