Evidence map›Paper›PMID 30322445›Full record

ArticleeLife2018

Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community.

Kevin D'hoe, Stefan Vet, Karoline Faust, Frédéric Moens, Gwen Falony, Didier Gonze, Verónica Lloréns-Rico, Lendert Gelens, Jan Danckaert, Luc De Vuyst and 1 more

Erratum issuedAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
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  4. Review
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  8. Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the Skin.JID innovations : skin science from molecules to population health · 2025
    Review
  9. Article
  10. Article
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  12. Article
  13. Review
  14. Article
  15. Lactate cross-feeding betweenApplied and environmental microbiology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Kevin D'hoe *Laboratory of Molecular Bacteriology, KU Leuven Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.
Stefan Vet *Applied Physics Research Group, Vrije Universiteit Brussel, Brussels, Belgium.ORCID http://orcid.org/0000-0001-7427-4459
Karoline Faust *Laboratory of Molecular Bacteriology, KU Leuven Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7129-2803
Frédéric MoensResearch Group of Industrial Microbiology and Food Biotechnology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Gwen FalonyLaboratory of Molecular Bacteriology, KU Leuven Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.
Didier GonzeUnité de Chronobiologie Théorique, Université Libre de Bruxelles, Brussels, Belgium.ORCID http://orcid.org/0000-0002-9800-2412
Verónica Lloréns-RicoLaboratory of Molecular Bacteriology, KU Leuven Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.ORCID https://orcid.org/0000-0002-0860-5990
Lendert GelensLaboratory of Dynamics in Biological Systems, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-7290-9561
Jan DanckaertApplied Physics Research Group, Vrije Universiteit Brussel, Brussels, Belgium.
Luc De Vuyst *Research Group of Industrial Microbiology and Food Biotechnology, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Jeroen Raes *Laboratory of Molecular Bacteriology, KU Leuven Department of Microbiology and Immunology, Rega Institute, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of the human gut microbiome is well resolved, but predictive understanding of its dynamics is still lacking. Here, we followed a bottom-up strategy to explore human gut community dynamics: we established a synthetic community composed of three representative human gut isolates (

Indexed as

BacteriaCells, CulturedComputer SimulationFermentationFormatesFructoseGastrointestinal MicrobiomeGene Expression Regulation, BacterialHumansKineticsMetabolomeModels, BiologicalProkaryotic CellsRNA, Ribosomal, 16SSpecies SpecificityTranscriptomeFormatesformic acidFructoseRNA, Ribosomal, 16SBlautia hydrogenotrophicacomputational biologyFaecalibacterium prausnitziiinfectious diseasemicrobiologyRoseburia intestinalissystems biology

Identifiers

PMID30322445
PMCPMC6237439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.