Evidence map›Paper›PMID 30322353›Full record

Trial reportOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2019

The Role of Oral Steroids in the Treatment of Phonotraumatic Vocal Fold Lesions in Women.

Milan R Amin, Stratos Achlatis, Shirley Gherson, Yixin Fang, Binhuan Wang, Hayley Born, Ryan C Branski, Aaron M Johnson

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Milan R Amin1 NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, USA.
Stratos Achlatis1 NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, USA.
Shirley Gherson1 NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, USA.
Yixin Fang3 Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey, USA.
Binhuan Wang4 Department of Population Heath, Division of Biostatistics, New York University School of Medicine, New York, New York, USA.
Hayley Born5 Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA.
Ryan C Branski1 NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, USA.
Aaron M Johnson1 NYU Voice Center, Department of Otolaryngology-Head and Neck Surgery, New York University School of Medicine, New York, New York, USA.
New York University · USNew Jersey Institute of Technology · USRusk Rehabilitation · USUniversity of Cincinnati · US

Funding

Translational Study of Vocal Exercise Dose-responseK23DC014517 · NIDCD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI JOHNSON, AARON MATTHEW · 2015 to 2019
$1.0M
NIDCD NIH HHS K23 DC014517
6 · The paper itself

Abstract

objectives(1) To determine the short-term effectiveness of oral steroids in women with benign vocal fold lesions and (2) to determine the effectiveness of adjuvant oral steroids in women undergoing voice therapy for benign vocal fold lesions. STUDY

designRandomized, double-blind, placebo-controlled clinical trial.

settingTertiary voice care center. SUBJECTS AND

methodsThirty-six patients undergoing voice therapy for the treatment of phonotraumatic vocal fold lesions randomly received either a 4-day course of oral steroids or a placebo prior to initiating voice therapy. Voice Handicap Index-10 (VHI-10) scores, video and audioperceptual analyses, acoustic and aerodynamic analyses at baseline, and patient perception of improvement after a short course of steroids or a placebo and at the conclusion of voice therapy were collected.

resultsThirty patients completed the study, of whom 27 (only female) were analyzed. The primary outcome measure, VHI-10, did not improve after the 4-day course of steroids or placebo. Secondary measures similarly showed no improvement with steroids relative to placebo. Voice therapy demonstrated a positive effect on both VHI-10 and patient-perceived improvement of voice in all subjects.

conclusionA short course of oral steroids did not benefit women with phonotraumatic vocal fold lesions. In addition, steroids had little beneficial effect when used adjunctively with voice therapy in this patient cohort.

Indexed as

Administration, OralAdultDouble-Blind MethodDrug Administration ScheduleFemaleGlucocorticoidsHumansLaryngeal DiseasesPrednisoneTreatment OutcomeVocal CordsVoice TrainingYoung AdultGlucocorticoidsPrednisoneglucocorticoidslarynxsteroidvocal foldvoicevoice therapy

Identifiers

PMID30322353
PMCPMC6842567
OpenAlexW2896879689

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.