Evidence map›Paper›PMID 30322266›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2018

Identification of miR-708-5p in peripheral blood monocytes: Potential marker for postmenopausal osteoporosis in Mexican-Mestizo population.

Aldo H De-La-Cruz-Montoya, Eric G Ramírez-Salazar, Mayeli M Martínez-Aguilar, Pablo M González-de-la-Rosa, Manuel Quiterio, Cei Abreu-Goodger, Jorge Salmerón, Rafael Velázquez-Cruz

Abstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Common miRNAs of Osteoporosis and Fibromyalgia: A Review.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Aldo H De-La-Cruz-Montoya1 Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City C.P. 14610, Mexico.ORCID 0000-0003-1096-579X
Eric G Ramírez-Salazar2 Consejo Nacional de Ciencia y Tecnología (CONACYT)-Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City C.P. 14610, Mexico.ORCID 0000-0002-0767-9357
Mayeli M Martínez-Aguilar1 Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City C.P. 14610, Mexico.
Pablo M González-de-la-Rosa3 Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Irapuato C.P. 3682, Mexico.
Manuel Quiterio4 Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Avenida Universidad 655, Morelos C.P. 6210, Mexico.
Cei Abreu-Goodger3 Laboratorio Nacional de Genómica para la Biodiversidad (Langebio), Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Irapuato C.P. 3682, Mexico.
Jorge Salmerón4 Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Avenida Universidad 655, Morelos C.P. 6210, Mexico.
Rafael Velázquez-Cruz1 Laboratorio de Genómica del Metabolismo Óseo, Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City C.P. 14610, Mexico.
National Institute of Genomic Medicine · MXFundación Biodiversidad · ESInstituto Nacional de Salud Pública · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementThis is the first study in which hsa-miR-708-5p has been identified in peripheral blood monocytes (osteoclast precursors) and associated with postmenopausal osteoporosis through small RNA-Sequencing, in an Admixed Mexican Mestizo population. By conducting in silico and bioinformatic analyzes, we identified target genes and important signaling pathways involved in bone metabolism pointing hsa-miR-708-5p as a candidate marker for osteoporosis in Mexican population. These approaches provide a landscape of the post-transcriptional regulation, which can be useful for the management of postmenopausal osteoporosis along with the potential use of microRNAs as markers for its early detection.

Indexed as

Gene Expression RegulationComputational BiologyGene Expression ProfilingHumansMexican AmericansMicroRNAsMonocytesOsteoclastsOsteoporosis, PostmenopausalSequence Analysis, RNAMicroRNAsMIRN708 microRNA, humanbiomarkersgenomicsmicroRNAsmonocyteosteoporosissmall RNA sequencing

Identifiers

PMID30322266
PMCPMC6434455
OpenAlexW2897595243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.