ArticleAsian spine journal2018
The Role of Vitamin D in the Pathogenesis of Adolescent Idiopathic Scoliosis.
Article in Asian spine journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Vitamin D in adolescent idiopathic scoliosis: a meta-analysis.BMC musculoskeletal disorders · 2023Pooled it
- Incidence of vitamin D deficiency in adolescent idiopathic scoliosis: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Association between calcium-phosphorus balance and adolescent idiopathic scoliosis: A meta-analysis.Acta orthopaedica et traumatologica turcica · 2019Pooled it
- Review
- Prevalence and determinants of adolescent idiopathic scoliosis from school screening in Xiaoshan District, Hangzhou, China.Frontiers in public health · 2025Article
- Variations in the prevalence of scoliosis by age, sex, geographic region, and subtype among Chinese children: A systematic review and modelling study.Journal of global health · 2024Article
- Gut Microbiota Alterations in Adolescent Idiopathic Scoliosis Are Associated with Aberrant Bone Homeostasis.Orthopaedic surgery · 2024Article
- Differences in Pubertal Curve Progression among Females with Adolescent Idiopathic Scoliosis Using Pregnenolone Therapy: A Retrospective Case-Controlled Series.Journal of clinical medicine · 2024Article
- Causal effects of specific gut microbiota on spinal stenosis diseases: a two-sample mendelian randomization study.Frontiers in genetics · 2024Article
- Article
- Association Among Complete Blood Count Parameters, Bone Mineral Density, and Cobb Angle in Cases of Adolescent Idiopathic Scoliosis.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Associations of physical activity and screen time with adolescent idiopathic scoliosis.Environmental health and preventive medicine · 2023Article
- Genetic Determinants of 25-Hydroxyvitamin D Concentrations and Their Relevance to Public Health.Nutrients · 2022Review
- Controlling the Progression of Curvature in Children and Adolescent Idiopathic Scoliosis Following the Administration of Melatonin, Calcium, and Vitamin D.Children (Basel, Switzerland) · 2022Article
- Salivary Progesterone Levels in Female Patients with a History of Idiopathic Scoliosis: A Retrospective Cross-Sectional Study.Clinics and practice · 2022Article
- Prevalence and Significance of Vitamin D Deficiency in Patients Undergoing Corrective Surgery for Adolescent Idiopathic Scoliosis.International journal of spine surgery · 2022Article
- Retrospective study of patterns of vitamin D testing and status at a single institution paediatric orthopaedics and sports clinics.BMJ open · 2021Article
- The Role of Vitamins in Neurodegenerative Disease: An Update.Biomedicines · 2021Review
- Vitamin D levels and pain outcomes in adolescent idiopathic scoliosis patients undergoing spine fusion.Spine deformity · 2021Article
- Assessment of serum vitamin D levels in surgical adolescent idiopathic scoliosis patients.BMC pediatrics · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several theories have been proposed to explain the etiology of adolescent idiopathic scoliosis (AIS) until present. However, limited data are available regarding the impact of vitamin D insufficiency or deficiency on scoliosis. Previous studies have shown that vitamin D deficiency and insufficiency are prevalent in adolescents, including AIS patients. A series of studies conducted in Hong Kong have shown that as many as 30% of these patients have osteopenia. The 25-hydroxyvitamin D3 level has been found to positively correlate with bone mineral density (BMD) in healthy adolescents and negatively with Cobb angle in AIS patients; therefore, vitamin D deficiency is believed to play a role in AIS pathogenesis. This study attempts to review the relevant literature on AIS etiology to examine the association of vitamin D and various current theories. Our review suggested that vitamin D deficiency is associated with several current etiological theories of AIS. We postulate that vitamin D deficiency and/or insufficiency affects AIS development by its effect on the regulation of fibrosis, postural control, and BMD. Subclinical deficiency of vitamin K2, a fat-soluble vitamin, is also prevalent in adolescents; therefore, it is possible that the high prevalence of vitamin D deficiency is related to decreased fat intake. Further studies are required to elucidate the possible role of vitamin D in the pathogenesis and clinical management of AIS.
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