Evidence map›Paper›PMID 30322188›Full record

ArticleMarine drugs2018

A Structure- and Ligand-Based Virtual Screening of a Database of "Small" Marine Natural Products for the Identification of "Blue" Sigma-2 Receptor Ligands.

Giuseppe Floresta, Emanuele Amata, Carla Barbaraci, Davide Gentile, Rita Turnaturi, Agostino Marrazzo, Antonio Rescifina

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

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  8. Artificial Intelligence Technologies for COVID-19 De Novo Drug Design.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Machine learningRSC advances · 2021
    Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Giuseppe FlorestaDepartment of Drug Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. giuseppe.floresta@unict.it.ORCID 0000-0002-0668-1260
Emanuele AmataDepartment of Chemical Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. eamata@unict.it.ORCID 0000-0002-4750-3479
Carla BarbaraciDepartment of Drug Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. carlabarbaraci@rocketmail.com.
Davide GentileDepartment of Drug Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. davide.gentile@studium.unict.it.
Rita TurnaturiDepartment of Drug Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. rita.turnaturi@unict.it.ORCID 0000-0002-5895-7820
Agostino MarrazzoDepartment of Drug Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. marrazzo@unict.it.ORCID 0000-0002-8728-8857
Antonio RescifinaDepartment of Drug Sciences, University of Catania, V.le A. Doria, 95125 Catania, Italy. arescifina@unict.it.ORCID 0000-0001-5039-2151
University of Catania · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sigma receptors are a fascinating receptor protein class whose ligands are actually under clinical evaluation for the modulation of opioid analgesia and their use as positron emission tomography radiotracers. In particular, peculiar biological and therapeutic functions are associated with the sigma-2 (σ₂) receptor. The

Indexed as

Aquatic OrganismsBiological ProductsCell DeathCell Line, TumorDatabases, ChemicalHumansLigandsMembrane ProteinsQuantitative Structure-Activity RelationshipReceptors, sigmaBiological ProductsLigandsMembrane ProteinsReceptors, sigmasigma-2 receptordatabase marine productssigma-2 receptorsigma-2 receptor ligandsvirtual screening

Identifiers

PMID30322188
PMCPMC6212963
OpenAlexW2896513870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.