Evidence map›Paper›PMID 30322183›Full record

ArticleMolecules (Basel, Switzerland)2018

Near Infrared Fluorophore-Tagged Chloroquine in

Li Yan Chan, Joshua Ding Wei Teo, Kevin Shyong-Wei Tan, Keitaro Sou, Wei Lek Kwan, Chi-Lik Ken Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Li Yan ChanDepartment of Technology, Innovation and Enterprise (TIE), Singapore Polytechnic, 500 Dover Road, Singapore 139651, Singapore. CHAN_Li_Yan@sp.edu.sg.ORCID 0000-0002-6778-7042
Joshua Ding Wei TeoDepartment of Technology, Innovation and Enterprise (TIE), Singapore Polytechnic, 500 Dover Road, Singapore 139651, Singapore. Joshua_TEO@sp.edu.sg.
Kevin Shyong-Wei TanLaboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, National University of Singapore, 5 Science Drive 2 Block MD4, Level 3, Singapore 117545, Singapore. mictank@nus.edu.sg.
Keitaro SouResearch Institute for Science and Engineering, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan. soukei@aoni.waseda.jp.ORCID 0000-0002-5449-9084
Wei Lek KwanEngineering Product Development, Singapore University of Technology and Design, 8 Somapah Road, Singapore 487372, Singapore. kwanwl@sutd.edu.sg.
Chi-Lik Ken LeeDepartment of Technology, Innovation and Enterprise (TIE), Singapore Polytechnic, 500 Dover Road, Singapore 139651, Singapore. Ken_LEE@sp.edu.sg.
Singapore Polytechnic · SGNational University of Singapore · SGSingapore University of Technology and Design · SGWaseda University · JP

Funding

Ministry of Education - Singapore MOE2012-TIF-1-T-051
6 · The paper itself

Abstract

Chloroquine was among the first of several effective drug treatments against malaria until the onset of chloroquine resistance. In light of diminished clinical efficacy of chloroquine as an antimalarial therapeutic, there is potential in efforts to adapt chloroquine for other clinical applications, such as in combination therapies and in diagnostics. In this context, we designed and synthesized a novel asymmetrical squaraine dye coupled with chloroquine (SQR1-CQ). In this study, SQR1-CQ was used to label live

Indexed as

AntimalarialsBloodChloroquineCyclobutanesDrug ResistanceFluorescent DyesHumansInhibitory Concentration 50Microscopy, ConfocalMolecular ImagingMolecular StructurePhenolsPlasmodium falciparumAntimalarialsChloroquineCyclobutanesFluorescent DyesPhenolssquarainechloroquinefluorescencemalarianear infraredPlasmodium falcipariumsquaraine dye

Identifiers

PMID30322183
PMCPMC6222297
OpenAlexW2893965393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.