ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019
APOE genotypes as a risk factor for age-dependent accumulation of cerebrovascular disease in older adults.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Amyloid-linked versus age-driven copathologies in Alzheimer's dementia: differential associations withResearch square · 2026Article
- Article
- Application of modified Poisson regression for risk estimation of major neuropathology outcomes: National Alzheimer's coordinating center.Journal of Alzheimer's disease : JAD · 2025Article
- Age-dependent interactions of APOE isoform 4 and Alzheimer's disease neuropathology: findings from the NACC.Acta neuropathologica communications · 2025Article
- A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury.Nature neuroscience · 2024Article
- Association of Alzheimer's Disease and Other Neuropathologies With Functional Disability in Persons With and Without Dementia.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Multifaceted roles of APOE in Alzheimer disease.Nature reviews. Neurology · 2024Review
- CCR5 deficiency: Decreased neuronal resilience to oxidative stress and increased risk of vascular dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebral Amyloid Angiopathy: An Undeniable Small Vessel Disease.Journal of stroke · 2024Review
- Association between APOE-ε4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample.Acta neuropathologica communications · 2023Review
- Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury.Research square · 2023Article
- Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.Acta neuropathologica communications · 2023Article
- Neuropathology-Independent Association BetweenNeurology. Genetics · 2023Article
- The vascular risk factors and vascular neuropathology in subjects with autopsy-confirmed dementia with Lewy bodies.International journal of geriatric psychiatry · 2022Article
- Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults.Cerebral circulation - cognition and behavior · 2022Article
- Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change and microvascular pathologies in community-dwelling older persons.Brain pathology (Zurich, Switzerland) · 2021Article
- Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy.Frontiers in aging neuroscience · 2021Article
- Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men.Journal of the International Neuropsychological Society : JINS · 2021Article
- APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study.Stroke · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionApolipoprotein E (APOE) is a susceptibility gene for late-onset Alzheimer's disease neuropathology; less is known about the relationship between APOE and cerebrovascular disease (CVD) neuropathology.
methodsWe investigated associations of APOE status with arteriolosclerosis, macroinfarcts and microinfarcts, and atherosclerosis in 1383 adults (65.9-108.2 years at death) with and without dementia. Excluding ε2/ε4 carriers, multivariable regressions for each CVD-related neuropathology compared ε4 and ε2 carriers to ε3/ε3 carriers adjusting for confounders including age and Alzheimer's neuropathology.
resultsThree hundred forty-two individuals (24.7%; ∼87.7 years at death; 39.9% nondemented) were ε3/ε4 or ε4/ε4, and 180 (13.0%; ∼89.9 years at death; 66.6% nondemented) were ε2/ε3 or ε2/ε2. ε4 carriers had higher odds of macroinfarcts (odds ratio = 1.41, 95% confidence interval: 1.02-1.94, P = .03), whereas ε2 carriers had higher odds of moderate-to-severe arteriolosclerosis (odds ratio = 1.68, 95% confidence interval: 1.15-2.45, P = .006) compared to ε3/ε3 carriers. Age-stratified analyses suggested that these relationships were driven by ε4 carriers <90 years at death and ε2 carriers ≥90 years at death, respectively. DISCUSSION: APOE differentially affects type and timing of CVD-related neuropathology.
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