Evidence map›Paper›PMID 30321335›Full record

ReviewEndocrine reviews2019

Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.

Roger Bouillon, Claudio Marcocci, Geert Carmeliet, Daniel Bikle, John H White, Bess Dawson-Hughes, Paul Lips, Craig F Munns, Marise Lazaretti-Castro, Andrea Giustina and 1 more

2 registry-linked trialsOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 629 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
629citing papers in PubMed, 13 pooled it
53.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06838520 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

A Prospective Study on the Impact of Androgen Deprivation Therapy (ADT) and Androgen Receptor Pathway Inhibitors (ARPI) on Bone Loss in Prostate Cancer Patients

TypeobservationalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2025 to 2030Enrolled200ConditionsProstate Cancer (Adenocarcinoma)ArmsBone health assessment
NCT07479303 completednot on this mapstarted 2025, after this paper: background citation

Evaluation of Vitamin D Status in Young Medical Residents at the Reina Sofia University Hospital in Cordoba

Typeobservational_patient_registrySponsorMaimónides Biomedical Research Institute of CórdobaRan2025 to 2025Enrolled30ConditionsVitamin D DeficiencyArmsCalcifediol (Vitamin D)
3 · Its place in the literature

Who cites it

629 citing papers in PubMed, 13 syntheses or guidelines pooled it, 1,075 citations in OpenAlex.

  1. Pooled it
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  6. The Lebanese GRADE-based vitamin D guidelines: a paradigm for the MENA region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Guideline
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  14. The Effect of Vitamin DJournal of the American Geriatrics Society · 2026
    Trial
  15. Kinetics and concentrations of circulating 25-hydroxyvitamin D using different vitamin D repletion regimens.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Trial
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569 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 7 countries.

Roger BouillonLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Belgium.
Claudio MarcocciDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Geert CarmelietLaboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Belgium.
Daniel BikleVeterans Affairs Medical Center and University of California San Francisco, San Francisco, California.
John H WhiteDepartment of Physiology, McGill University, Montreal, Quebec, Canada.
Bess Dawson-HughesJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
Paul LipsDepartment of Internal Medicine, Endocrine Section, VU University Medical Center, HV Amsterdam, Netherlands.
Craig F MunnsChildren's Hospital at Westmead, Sydney, New South Wales, Australia.
Marise Lazaretti-CastroDivision of Endocrinology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Andrea GiustinaChair of Endocrinology, Vita-Salute San Raffaele University, Milan, Italy.
John BilezikianDepartment of Endocrinology, Columbia University College of Physicians and Surgeons, New York, New York.
KU Leuven · BEAmsterdam UMC Location Vrije Universiteit Amsterdam · NLColumbia University · USMcGill University · CASan Francisco VA Medical Center · USThe University of Sydney · AUTufts University · USUniversidade Federal de São Paulo · BRUniversity of Pisa · ITVita-Salute San Raffaele University · IT

Funding

PRIMARY HYPERPARATHYROIDISMR01DK032333 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BILEZIKIAN, JOHN P · 1986 to 2018
$9.6M
Role of IGF-I/integrin signaling in the periosteal response to loadR01AR055924 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BIKLE, DANIEL DAVID · 2008 to 2019
$3.5M
ATP2A2-Regulated Keretinocyted Ca2+ Signaling MechanismsR01AR051930 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2006 to 2019
$3.2M
Role of vitamin D and calcium signaling in wound healingI01BX001066 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2011 to 2014
–
Vitamin D and Calcium signaling in epidermal stem cell maintenance, activation, and functionI01BX003814 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2018 to 2021
–
BLRD VA I01 BX001066BLRD VA I01 BX003814NIAMS NIH HHS R01 AR051930NIAMS NIH HHS R01 AR055924NIDDK NIH HHS R01 DK032333
6 · The paper itself

Abstract

The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of 25-hydroxyvitamin D and other metabolites, including 1,25(OH)2D, the ligand for the vitamin D receptor (VDR). The effects of the vitamin D endocrine system on bone and its growth plate are primarily indirect and mediated by its effect on intestinal calcium transport and serum calcium and phosphate homeostasis. Rickets and osteomalacia can be prevented by daily supplements of 400 IU of vitamin D. Vitamin D deficiency (serum 25-hydroxyvitamin D <50 nmol/L) accelerates bone turnover, bone loss, and osteoporotic fractures. These risks can be reduced by 800 IU of vitamin D together with an appropriate calcium intake, given to institutionalized or vitamin D-deficient elderly subjects. VDR and vitamin D metabolic enzymes are widely expressed. Numerous genetic, molecular, cellular, and animal studies strongly suggest that vitamin D signaling has many extraskeletal effects. These include regulation of cell proliferation, immune and muscle function, skin differentiation, and reproduction, as well as vascular and metabolic properties. From observational studies in human subjects, poor vitamin D status is associated with nearly all diseases predicted by these extraskeletal actions. Results of randomized controlled trials and Mendelian randomization studies are supportive of vitamin D supplementation in reducing the incidence of some diseases, but, globally, conclusions are mixed. These findings point to a need for continued ongoing and future basic and clinical studies to better define whether vitamin D status can be optimized to improve many aspects of human health. Vitamin D deficiency enhances the risk of osteoporotic fractures and is associated with many diseases. We review what is established and what is plausible regarding the health effects of vitamin D.

Indexed as

AnimalsBone and BonesCalciumFemaleHumansMaleOsteomalaciaRicketsSignal TransductionVitamin DVitamin D DeficiencyCalciumVitamin D

Identifiers

PMID30321335
PMCPMC6626501
OpenAlexW2896178057

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.