ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Marmoset as a Model to Study Kidney Changes Associated With Aging.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Histological characterization of major internal organs in infant common marmosets (Callithrix jacchus).PloS one · 2026Article
- Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025Review
- Pseudomonas Infections in the Common Marmoset (Callithrix jacchus): Gross and Histopathological Findings.Journal of medical primatology · 2025Article
- ABI3BP promotes renal aging through Klotho-mediated ferroptosis.Journal of translational medicine · 2024Article
- Age-related changes in hematological biomarkers in common marmosets.American journal of primatology · 2024Article
- Cinnamaldehyde attenuates kidney senescence and injury through PI3K/Akt pathway-mediated autophagy via downregulating miR-155.Renal failure · 2022Article
- Factors Affecting Hematologic and Serum Biochemical Parameters in Healthy Common Marmosets (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Hydrogen sulfide in ageing, longevity and disease.The Biochemical journal · 2021Review
- Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.Aging cell · 2021Article
- Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.JCI insight · 2021Article
- Article
- Hydrogen Sulfide and the Kidney.Advances in experimental medicine and biology · 2021Article
- Urogenital Lesions in Nonhuman Primates at 2 National Primate Research Centers.Veterinary pathology · 2021Article
- Clinical Management of Gastrointestinal Disease in the Common Marmoset (Callithrix jacchus).ILAR journal · 2020Review
- An Emergent Integrated Aging Process Conserved Across Primates.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Review
- Cross-sectional comparison of health-span phenotypes in young versus geriatric marmosets.American journal of primatology · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
We evaluated whether the marmoset, a nonhuman primate, can serve as a good model to study aging-related changes in the kidney by employing healthy young and aged marmosets of both sexes. Aging was associated with glomerulosclerosis, interstitial fibrosis, and arteriolosclerosis in both sexes; correspondingly, the content of matrix proteins was increased. Functionally, aging resulted in an increase in urinary albumin and protein excretion. There was a robust correlation between markers of fibrosis and functional changes. We explored signaling pathways as potential mechanistic events. Aging in males, but not in females, was associated with reduced renal cortical activity of AMP-activated protein kinase (AMPK) and a trend toward activation of mechanistic target of rapamycin complex 1 (mTORC1); upstream of AMPK and mTORC1, Akt and IGF-1 receptor were activated. In both sexes, aging promoted kidney activation of transforming growth factor β-1 signaling pathway. While the expression of cystathionine β-synthase (CBS), an enzyme involved hydrogen sulfide (H2S) synthesis, was reduced in both aged males and females, decreased H2S generation was seen in only males. Our studies show that the marmoset is a valid model to study kidney aging; some of the signaling pathways involved in renal senescence differ between male and female marmosets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.