ArticleCerebral cortex (New York, N.Y. : 1991)2019
Cortical Balance Between ON and OFF Visual Responses Is Modulated by the Spatial Properties of the Visual Stimulus.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Sustained Plus Lens Defocus Alters Retinal Responses and Ciliary Muscle Morphology In Myopes and Near-emmetropes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Human accommodative visuomotor function is driven by contrast through ON and OFF pathways and is enhanced in myopia.Cell reports · 2026Article
- Direction-selective laterodorsal thalamic nucleus encodes optic flow and turning in spatial navigation.Neuron · 2025Article
- Do the receptive fields in the primary visual cortex span a variability over the degree of elongation of the receptive fields?Journal of computational neuroscience · 2025Article
- Article
- Retinal Responses to Short- and Longer-Term Predominant ON or OFF Stimulation in Emmetropes and Myopes.Investigative ophthalmology & visual science · 2025Article
- Visual Field Asymmetries in Responses to ON and OFF Pathway Biasing Stimuli.Visual neuroscience · 2024Article
- Good vision without peripheries: behavioral and fMRI evidence.Scientific reports · 2024Article
- Plaid masking explained with input-dependent dendritic nonlinearities.Scientific reports · 2024Article
- Contrast Sensitivity of ON and OFF Human Retinal Pathways in Myopia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Effects of computer-generated patterns with different temporal and spatial frequencies on choroidal thickness, retinal dopamine and candidate genes in chickens wearing lenses.Frontiers in medicine · 2024Article
- Dynamic Recruitment of the Feedforward and Recurrent Mechanism for Black-White Asymmetry in the Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- ON and OFF receptive field processing in the presence of optical scattering.Biomedical optics express · 2023Article
- Differences in visual stimulation between reading and walking and implications for myopia development.Journal of vision · 2023Article
- Model-Based Approach Shows ON Pathway Afferents Elicit a Transient Decrease of V1 Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Luminance Contrast Shifts Dominance Balance between ON and OFF Pathways in Human Vision.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- State-of-the-art image and video quality assessment with a metric based on an intrinsically non-linear neural summation model.Frontiers in neuroscience · 2023Article
- Preferential Loss of Contrast Decrement Responses in Human Glaucoma.Investigative ophthalmology & visual science · 2022Article
- Cortical mechanisms of visual brightness.Cell reports · 2022Article
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The primary visual cortex of carnivores and primates is dominated by the OFF visual pathway and responds more strongly to dark than light stimuli. Here, we demonstrate that this cortical OFF dominance is modulated by the size and spatial frequency of the stimulus in awake primates and we uncover a main neuronal mechanism underlying this modulation. We show that large grating patterns with low spatial frequencies drive five times more OFF-dominated than ON-dominated neurons, but this pronounced cortical OFF dominance is strongly reduced when the grating size decreases and the spatial frequency increases, as when the stimulus moves away from the observer. We demonstrate that the reduction in cortical OFF dominance is not caused by a selective reduction of visual responses in OFF-dominated neurons but by a change in the ON/OFF response balance of neurons with diverse receptive field properties that can be ON or OFF dominated, simple, or complex. We conclude that cortical OFF dominance is continuously adjusted by a neuronal mechanism that modulates ON/OFF response balance in multiple cortical neurons when the spatial properties of the visual stimulus change with viewing distance and/or optical blur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.