ArticlePloS one2018
Orchestrated regulation of iron trafficking proteins in the kidney during iron overload facilitates systemic iron retention.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Review
- Iron Compartmentalisation and Vascular Endothelial Cell Dysfunction.Antioxidants (Basel, Switzerland) · 2026Review
- Iron-related protein in prediction of acute kidney injury in the pediatric population after cardiac surgery.Journal of cardiothoracic surgery · 2025Article
- Transferrin receptors.Experimental & molecular medicine · 2025Review
- Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments.Nature communications · 2024Article
- Advance in Iron Metabolism, Oxidative Stress and Cellular Dysfunction in Experimental and Human Kidney Diseases.Antioxidants (Basel, Switzerland) · 2024Review
- Amelioration of nephrotoxicity by targeting ferroptosis: role of NCOA4, IREB2, and SLC7a11 signaling.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Article
- Iron metabolism and chronic inflammation in IgA nephropathy.Renal failure · 2023Review
- Animal models of kidney iron overload and ferroptosis: a review of the literature.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Iron Deficiency and Nephrotoxic Heavy Metals: A Dangerous Interplay?International journal of molecular sciences · 2023Review
- Iron dyshomeostasis and time-course changes in iron-uptake systems and ferritin level in relation to pro-inflammatory microglia polarization in sepsis-induced encephalopathy.Frontiers in physiology · 2022Article
- Dysregulation of the sensory and regulatory pathways controlling cellular iron metabolism in unilateral obstructive nephropathy.American journal of physiology. Renal physiology · 2022Article
- Ferrostatin-1 Ameliorates Liver Dysfunction via Reducing Iron in Thioacetamide-induced Acute Liver Injury in Mice.Frontiers in pharmacology · 2022Article
- Therapeutic Implications of Ferroptosis in Renal Fibrosis.Frontiers in molecular biosciences · 2022Review
- Effect of embedded metal fragments on urinary metal levels and kidney biomarkers in the Sprague-Dawley rat.Toxicology reports · 2021Article
- Ferritins in Kidney Disease.Seminars in nephrology · 2020Review
- The multifaceted role of iron in renal health and disease.Nature reviews. Nephrology · 2020Review
- Evidence of Renal Iron Accumulation in a Male Mouse Model of Lupus.Frontiers in medicine · 2020Article
- Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice.Scientific reports · 2019Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The exact route of iron through the kidney and its regulation during iron overload are not completely elucidated. Under physiologic conditions, non-transferrin and transferrin bound iron passes the glomerular filter and is reabsorbed through kidney epithelial cells, so that hardly any iron is found in the urine. To study the route of iron reabsorption through the kidney, we analyzed the location and regulation of iron metabolism related proteins in kidneys of mice with iron overload, elicited by iron dextran injections. Transferrin Receptor 1 was decreased as expected, following iron overload. In contrast, the multi-ligand hetero-dimeric receptor-complex megalin/cubilin, which also mediates the internalization of transferrin, was highly up-regulated. Moreover, with increasing iron, intracellular ferritin distribution shifted in renal epithelium from an apical location to a punctate distribution throughout the epithelial cells. In addition, in contrast to many other tissues, the iron exporter ferroportin was not reduced by iron overload in the kidney. Iron accumulated mainly in interstitial macrophages, and more prominently in the medulla than in the cortex. This suggests that despite the reduction of Transferrin Receptor 1, alternative pathways may effectively mediate re-absorption of iron that cycles through the kidney during parenterally induced iron-overload. The most iron consuming process of the body, erythropoiesis, is regulated by the renal erythropoietin producing cells in kidney interstitium. We propose, that the efficient re-absorption of iron by the kidney, also during iron overload enables these cells to sense systemic iron and regulate its usage based on the systemic iron state.
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Registered trials
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