Evidence map›Paper›PMID 30321021›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2018

Fatigue after breast cancer treatment: Biobehavioral predictors of fatigue trajectories.

Julienne E Bower, Joshua Wiley, Laura Petersen, Michael R Irwin, Steve W Cole, Patricia A Ganz

Open access · hybridAbstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Adverse childhood events and mental health problems in cancer survivors: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  2. Effects of sleep interventions on cancer-related fatigue and quality of life in cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  3. Mindfulness-Based Cancer Recovery (MBCR) training: the efficacy on fatigue and sleep quality of Iranian female patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  4. Patient-Reported Outcomes in OlympiA: A Phase III, Randomized, Placebo-Controlled Trial of Adjuvant Olaparib in gJournal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Trial
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  7. Moderators of physical activity and quality of life response to a physical activity intervention for breast cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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  11. Targeted self-management limits fatigue for women undergoing radiotherapy for early breast cancer: results from the ACTIVE randomised feasibility trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Trial
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  19. Current status and influencing factors of cancer-related fatigue in gastric cancer patients undergoing chemotherapy: A cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Julienne E BowerDepartment of Psychology, University of California, Los Angeles.
Joshua WileyMonash University.
Laura PetersenDivision of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLA.
Michael R IrwinDepartment of Psychology, University of California, Los Angeles.
Steve W ColeCousins Center for Psychoneuroimmunology, Semel Institute at University of California, Los Angeles.
Patricia A GanzDivision of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center at UCLA.
University of California, Los Angeles · USUCLA Jonsson Comprehensive Cancer CenterAustralian Regenerative Medicine Institute · AU

Funding

Cognitive Functioning After Breast Cancer TreatmentR01CA109650 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GANZ, PATRICIA A. · 2006 to 2010
$2.2M
Breast Cancer Research FoundationCousins Center for PsychoneuroimmunologyNational Institutes of HealthNCI NIH HHS R01 CA109650
6 · The paper itself

Abstract

objectiveFatigue is a common side effect of cancer treatment, but there is considerable variability in fatigue severity and persistence among survivors. This study aimed to characterize longitudinal trajectories of fatigue after breast cancer treatment and to identify predictors of varying fatigue trajectories.

methodsWomen (N = 191) from the Mind-Body Study completed assessments after primary treatment for early stage breast cancer and at regular follow-ups that occurred up to 6 years after treatment (M = 4.3 years). Growth mixture models were used to characterize fatigue trajectories, and demographic, medical, and biobehavioral risk factors were examined as predictors of trajectory group.

resultsFive trajectories were identified, characterized as High, Recovery, Late, Low, and Very Low fatigue. The High and Recovery groups (40% of sample) evidenced elevated fatigue at posttreatment that declined in Recovery but persisted in the High group. In bivariate analyses, trajectory groups differed significantly on depressive symptoms, sleep disturbance, childhood adversity, body mass index, and the inflammatory marker soluble TNF receptor type II, which were higher in the High and/or Recovery groups. In multivariate models, depressive symptoms and childhood adversity distinguished High and Recovery from other groups. Rates of chemotherapy were higher in the Recovery than in the High or Late group, whereas rates of endocrine therapy were higher in the High than in the Recovery group.

conclusionsThere are distinct longitudinal trajectories of fatigue after breast cancer treatment. Psychological factors are strongly associated with adverse fatigue trajectories, and together with treatment exposures may increase risk for cancer-related fatigue. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Indexed as

Antineoplastic AgentsBiomarkersBody Mass IndexBreast NeoplasmsDepressionFatigueFemaleFollow-Up StudiesHumansMastectomyMiddle AgedRadiotherapyRisk FactorsSleep Wake DisordersAntineoplastic AgentsBiomarkers

Identifiers

PMID30321021
PMCPMC6372460
OpenAlexW2897690276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.