SynthesisJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019
Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies.
Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph
Synthesis in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
What it found
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- The genetic architecture of hip shape and its role in the development of hip osteoarthritis and fracture.Human molecular genetics · 2025Pooled it
- Genetics of hip dysplasia - a systematic literature review.BMC musculoskeletal disorders · 2024Pooled it
- An updated meta-analysis of the association between fibroblast growth factor receptor 4 polymorphisms and susceptibility to cancer.Bioscience reports · 2020Pooled it
- Childhood growth associated with hip shapes at skeletal maturity: the Bergen Hip Cohort Study.BMC musculoskeletal disorders · 2025Trial
- DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- The Scientific Case for Animal Models: A Perspective From Musculoskeletal Researchers.FASEB bioAdvances · 2026Article
- Complex Regulatory Interactions at GDF5 Shape Joint Morphology and Osteoarthritis Disease Risk.Arthritis & rheumatology (Hoboken, N.J.) · 2025Article
- Differential regulation of coronal and lambdoid suture patency by PTHLH and HHIP activity in mice.Development (Cambridge, England) · 2025Article
- Genetics of morphological hip abnormalities and their implications for osteoarthritis: a scoping review.Journal of hip preservation surgery · 2025Review
- The methylomic landscape of human articular cartilage development contains epigenetic signatures of osteoarthritis risk.American journal of human genetics · 2024Article
- Article
- Transcriptional profiling of human cartilage endplate cells identifies novel genes and cell clusters underlying degenerated and non-degenerated phenotypes.Arthritis research & therapy · 2024Article
- Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research.Current osteoporosis reports · 2023Review
- Leveraging osteoclast genetic regulatory data to identify genes with a role in osteoarthritis.Genetics · 2023Article
- Runx1 is a key regulator of articular cartilage homeostasis by orchestrating YAP, TGFβ, and Wnt signaling in articular cartilage formation and osteoarthritis.Bone research · 2022Article
- Osteoarthritis - Insights From Recent Research.Journal of rheumatic diseases · 2022Review
- Review
- Statistical Shape and Appearance Models: Development Towards Improved Osteoporosis Care.Current osteoporosis reports · 2021Review
- Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank.Osteoarthritis and cartilage · 2021Article
- The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.Calcified tissue international · 2021Review
Corrections and comments
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Authors and funding
30 authors at 17 institutions in 7 countries.
Denis A BairdMusculoskeletal Research Unit, University of Bristol, Bristol, UK.
Daniel S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Frederick K KamanuInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Jennifer S GregoryArthritis and Musculoskeletal Medicine, University of Aberdeen, Aberdeen, UK.
Fiona R SaundersArthritis and Musculoskeletal Medicine, University of Aberdeen, Aberdeen, UK.
Claudiu V GiuraniucArthritis and Musculoskeletal Medicine, University of Aberdeen, Aberdeen, UK.
Rebecca J BarrArthritis and Musculoskeletal Medicine, University of Aberdeen, Aberdeen, UK.
Richard M AspdenArthritis and Musculoskeletal Medicine, University of Aberdeen, Aberdeen, UK.
Deborah JenkinsMusculoskeletal Research Unit, University of Bristol, Bristol, UK.
Douglas P KielInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Eric S OrwollSchool of Medicine, Oregon Health and Science University, Portland, OR, USA.
Steven R CummingsCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
Nancy E LaneUniversity of California at Davis, Sacramento, CA, USA.
Benjamin H MullinDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.
Frances Mk WilliamsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
J Brent RichardsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Scott G WilsonDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Australia.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Benjamin G FaberMusculoskeletal Research Unit, University of Bristol, Bristol, UK.
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Elin GrundbergDepartment of Human Genetics, McGill University, Montreal, Canada.
Claes OhlssonCentre for Bone and Arthritis Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Ulrika Pettersson-KymmerDepartment of Pharmacology and Clinical Neurosciences, Umea University, Umea, Sweden.
Terence D CapelliniBroad Institute of MIT and Harvard, Boston, MA, USA.
Daniel RichardHuman Evolutionary Biology, Harvard University, Boston, MA, USA.
Thomas J BeckBeck Radiological Innovations, Catonsville, MD, USA.
David M EvansMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Lavinia PaternosterMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
David KarasikInstitute for Aging Research, Hebrew SeniorLife, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Jonathan H TobiasMusculoskeletal Research Unit, University of Bristol, Bristol, UK.
University of Bristol · GBUniversity of Aberdeen · GBKing's College London · GBBeth Israel Deaconess Medical Center · USBroad Institute · USThe University of Western Australia · AUBecs Technology (United States) · USCalifornia Pacific Medical Center · USHarvard University · USMcGill Genome Centre · CAOregon Health & Science University · USThe University of Queensland · AUTranslational Research Institute · AUUmeå University · SEUniversity of California, Davis · USUniversity of Dundee · GBUniversity of Gothenburg · SE
Funding
THE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8MOregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4MOregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7MStudy of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2MRISK FACTORS FOR VERTEBRAL FRACTURE AND BONE LOSSR01AR041398 · NIAMS · RHODE ISLAND HOSPITAL (PROVIDENCE, RI) · PI KIEL, DOUGLAS P. · 1991 to 2025
$16.1MOsteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3MSNP HEALTH ASSOCIATION RESOURCE (SHARE)N02HL64278 · NHLBI · PI CHIN, SIANG · 2007 to 2007
$9.2MThe Gut Microbiome and Bone MicroarchitectureR01AR061445 · NIAMS · HEBREW REHABILITATION CENTER FOR AGED · PI KIEL, DOUGLAS P. · 2012 to 2021
$8.9MStudy of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1MGWAS in MrOS and SOFRC2AR058973 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2009 to 2010
$5.7MIntegrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3MOsteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3MMedical Research Council G1001357Medical Research Council G9815508Medical Research Council MC_PC_19009Medical Research Council MC_UU_12013/4Medical Research Council MC_UU_12013/5Medical Research Council MR/M004422/1NCATS NIH HHS UL1 TR000128NCATS NIH HHS UL1 TR002369NHLBI NIH HHS N01HC25195NHLBI NIH HHS N02 HL64278NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS R01 AR041398NIAMS NIH HHS R01 AR050066NIAMS NIH HHS R01 AR051124NIAMS NIH HHS R01 AR061162NIAMS NIH HHS R01 AR061445NIAMS NIH HHS R01 AR070139NIAMS NIH HHS RC2 AR058973NIAMS NIH HHS U01 AR066160NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168NIA NIH HHS U24 AG051129Versus Arthritis 20244Wellcome TrustWellcome Trust WT088806Wellcome Trust WT092830MWellcome Trust WT102215/2/13/2
Abstract
We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray absorptiometry (DXA)-derived hip shape, which is thought to be related to the risk of both hip osteoarthritis and hip fracture. Ten hip shape modes (HSMs) were derived by statistical shape modeling using SHAPE software, from hip DXA scans in the Avon Longitudinal Study of Parents and Children (ALSPAC; adult females), TwinsUK (mixed sex), Framingham Osteoporosis Study (FOS; mixed), Osteoporotic Fractures in Men study (MrOS), and Study of Osteoporotic Fractures (SOF; females) (total N = 15,934). Associations were adjusted for age, sex, and ancestry. Five genomewide significant (p < 5 × 10
Indexed as
Femur HeadGenetic LociLinkage DisequilibriumPolymorphism, Single NucleotideAnimalsBone DensityGenome-Wide Association StudyHip FracturesHumansLongitudinal StudiesMiceOsteoporotic FracturesDXAGWASHIP FRACTURE RISKHIP SHAPEOSTEOARTHRITIS
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.