ArticleJournal of clinical laboratory analysis2019
What makes D-dimer assays suspicious-heterophilic antibodies?
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Application and concentration selection of dithiothreitol for correcting false elevation of D-dimer.Practical laboratory medicine · 2025Article
- D-dimer assay interference detected by the discrepancy in D-dimer concentrations at different dilutions: a case report.Biochemia medica · 2024Article
- Prognostic value of coagulation markers in patients with colorectal caner: A prospective study.Health science reports · 2024Article
- Heterophilic antibodies leading to falsely positive D-dimer concentration in an adolescent.Research and practice in thrombosis and haemostasis · 2023Article
- D-dimer Testing in Pulmonary Embolism with a Focus on Potential Pitfalls: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Analytical performance of a new immunoturbidimetric D-dimer assay and comparison with available assays.Research and practice in thrombosis and haemostasis · 2022Article
- Disseminated Intravascular Coagulation Score and Sepsis-induced Coagulopathy Score in Prediction of COVID-19 Severity: A Retrospective Analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Different diagnostic performance of plasma fibrinogen and D-dimer in periprosthetic joint infection: a propensity score matched study.BMC musculoskeletal disorders · 2021Article
- Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study.Clinics (Sao Paulo, Brazil) · 2021Article
- Verification of automated latex-enhanced particle immunoturbidimetric D-Dimer assays on different analytical platforms and comparability of test results.Biochemia medica · 2020Article
- Clinical laboratory investigation of a patient with an extremely high D-dimer level: A case report.World journal of clinical cases · 2020Article
- False-positive troponin I elevation in a newborn with neonatal encephalopathy.BMJ case reports · 2019Article
- What makes D-dimer assays suspicious-heterophilic antibodies?Journal of clinical laboratory analysis · 2019Article
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7 authors.
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Abstract
backgroundHeterophilic antibodies are still an important source of interference in immunoassays, but reports of interference with D-dimers are rare. Are D-dimer level abnormalities, found in the clinic, caused by heterophilic antibodies as well, or are other mechanisms involved? We will elaborate on this issue through two different examples in this article.
methodsSerum from two patients with significantly elevated levels of D-dimers were measured and compared by different methods, diluted, and dealt with heterophilic antibody blockers. At the same time, to retrieve the interference, we focused on the cause of D-dimer false positives and made a systematic review of the literature.
resultsThe D-dimer values were normal (0.49 and 0.15 μg/mL) detected with different testing method and decreased after addition of heterophilic antibody blocking reagent. According to literature data, there were 66.7% (4/6) references showed the interference were heterophilic antibody.
conclusionsThe influence of heterophilic antibodies on the measurement of D-dimers remains a big challenge. Different measuring instruments and methods may have significant differences in the measurement of D-dimers. By using a combination of instrumental methods for measuring, incorporating heterophilic antibody blockers, and combining with clinical performance and imaging data, most of the interference can be eliminated.
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