ArticleACS omega2018
Exploring the Inhibitory and Antioxidant Effects of Fullerene and Fullerenol on Ribonuclease A.
Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- The advent of molecular nanocarbon biology.Chemical science · 2026Review
- Carbon-based nanomaterials in biomedicine and technology.Frontiers in chemistry · 2026Review
- Effect of Fullerenol CMolecules (Basel, Switzerland) · 2025Article
- Distinctive Effects of Fullerene CAntioxidants (Basel, Switzerland) · 2025Article
- An Explicative Review on Nanotechnology-based Drug Delivery Systems for Alleviating Oxidative Stress-driven Pathologies.Current drug metabolism · 2025Review
- Research Progress on Using Nanoparticles to Enhance the Efficacy of Drug Therapy for Chronic Mountain Sickness.Pharmaceutics · 2024Review
- Reactive Oxygen Species Scavenging Capacity of Functional Fullerenes in Solution and in Macrophage Cells.ACS applied nano materials · 2024Article
- Innovating Leishmaniasis Treatment: A Critical Chemist's Review of Inorganic Nanomaterials.ACS infectious diseases · 2024Review
- Carbon-Based Nanomaterials Decorated Electrospun Nanofibers in Biosensors: A Review.ACS omega · 2024Review
- A Molecular Dynamics Simulation of Complexes of Fullerenes and Lysine-Based Peptide Dendrimers with and without Glycine Spacers.International journal of molecular sciences · 2024Article
- Chemical Profiling and Antioxidant and Anti-Amyloid Capacities ofPlants (Basel, Switzerland) · 2023Article
- Incorporating the Antioxidant Fullerenol into Calcium Phosphate Bone Cements Increases Cellular Osteogenesis without Compromising Physical Cement Characteristics.Advanced engineering materials · 2023Article
- Structure and Vibrational Spectroscopy of CMolecules (Basel, Switzerland) · 2023Article
- Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience.Biomedical engineering online · 2023Review
- Polyhydroxylated Fullerene CJournal of inflammation research · 2023Article
- Novel CMolecules (Basel, Switzerland) · 2022Article
- Carbon Nanomaterials (CNMs) and Enzymes: From Nanozymes to CNM-Enzyme Conjugates and Biodegradation.Materials (Basel, Switzerland) · 2022Review
- Dissecting the Supramolecular Dispersion of Fullerenes by Proteins/Peptides: Amino Acid Ranking and Driving Forces for Binding to CInternational journal of molecular sciences · 2021Article
- Biomedical Applications of Carbon Nanomaterials: Fullerenes, Quantum Dots, Nanotubes, Nanofibers, and Graphene.Materials (Basel, Switzerland) · 2021Review
- Antioxidant Potential of Aqueous Dispersions of Fullerenes CInternational journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fullerene-protein interaction studies have been a key topic of investigation in recent times, but the lower water solubility of fullerene somewhat limits its application in the biological system. In this work, we have compared the activities of fullerene and its water-soluble hydrated form, that is fullerenol, on ribonuclease A (RNase A) under physiological conditions (pH 7.4). The interaction studies of fullerene and fullerenol with protein suggest that the binding depends on the hydrophobic interactions between the protein and the ligand. In addition, fullerene and fullerenol slow down the ribonucleolytic activity of RNase A through noncompetitive and mixed types of inhibition, respectively. This precisely gives the idea about the ligand-binding sites in RNase A, which has further been explored using docking studies. Both these nanoparticles show a reduction in dityrosine formation in RNase A caused due to oxidative stress and also prevent RNase A dimer formation to different extents depending on their concentration.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.