Evidence map›Paper›PMID 30320262›Full record

ArticleACS omega2018

Biological Evaluation and Docking Studies of Synthetic Oleanane-type Triterpenoids.

Mariano Ortega-Muñoz, Fernando Rodríguez-Serrano, Eduardo De Los Reyes-Berbel, Nuria Mut-Salud, Fernando Hernández-Mateo, Andrea Rodríguez-López, José M Garrido, F Javier López-Jaramillo, Francisco Santoyo-González

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Terpenoids as Potential Geroprotectors.Antioxidants (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Mariano Ortega-MuñozDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Fernando Rodríguez-SerranoDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Eduardo De Los Reyes-BerbelDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Nuria Mut-SaludDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Fernando Hernández-MateoDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Andrea Rodríguez-LópezDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
José M GarridoDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
F Javier López-JaramilloDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Francisco Santoyo-GonzálezDepartment of Organic Chemistry, Faculty of Sciences, Department of Organic Chemistry, Biotechnology Institute, Institute of Biopathology and Regenerative Medicine (IBIMER), and Department of Human Anatomy and Embryology, University of Granada, 18071 Granada, Spain.
Universidad de Granada · ESInstituto de Investigación Biosanitaria de Granada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Saponins are potential wide-spectrum antitumor drugs, and copper(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition is a suitable approach to synthesizing saponin-like compounds by regioselective glycosylation of the C2/C3 hydroxyl and C28 carboxylic groups of triterpene aglycones maslinic acid (MA) and oleanolic acid (OA). Biological studies on the T-84 human colon carcinoma cell line support the role of the hydroxyl groups at C2/C3, the influence of the aglycone, and the bulky nature of the substituents in C28. OA bearing a α-d-mannose moiety at C28 (compound

Identifiers

PMID30320262
PMCPMC6173505
OpenAlexW2890536710

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.