Evidence map›Paper›PMID 30320210›Full record

ArticleTomography (Ann Arbor, Mich.)2018

Renal Energy Metabolism Following Acute Dichloroacetate and 2,4-Dinitrophenol Administration: Assessing the Cumulative Action with Hyperpolarized [1-

Lotte Bonde Bertelsen, Per Mose Nielsen, Haiyun Qi, Christian Østergaard Mariager, Jakob Lindhardt, Christoffer Laustsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lotte Bonde BertelsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Per Mose NielsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Haiyun QiMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Christian Østergaard MariagerMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Jakob LindhardtMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Christoffer LaustsenMR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Aarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous patient groups receive >1 medication and as such represent a potential point of improvement in today's healthcare setup, as the combined or cumulative effects are difficult to monitor in an individual patient. Here we show the ability to monitor the pharmacological effect of 2 classes of medications sequentially, namely, 2,4-dinitrophenol, a mitochondrial uncoupler, and dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, both targeting the oxygen-dependent energy metabolism. We show that although the 2 drugs target 2 different metabolic pathways connected ultimately to oxygen metabolism, we could distinguish the 2 in vivo by using hyperpolarized [1-

Indexed as

2,4-DNPDCAhyperpolarizationmetabolismMRI

Identifiers

PMID30320210
PMCPMC6173791
OpenAlexW2796115665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.