ArticleFrontiers in cardiovascular medicine2018
Discrete Subaortic Stenosis: Perspective Roadmap to a Complex Disease.
Article in Frontiers in cardiovascular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Shear Stress Initiates Endothelial-to-Mesenchymal Transition in Endocardial Endothelial Cells.Annals of biomedical engineering · 2026Article
- Risk Factors for Reintervention in Children with Subvalvular Aortic Stenosis: A 20-Year Single-Center Study.Journal of cardiovascular development and disease · 2025Article
- Surgical management of recurrent subaortic stenosis: a case report of the modified Konno operation.Journal of surgical case reports · 2025Article
- Article
- Shear Stress Induces a Time-Dependent Inflammatory Response in Human Monocyte-Derived Macrophages.Annals of biomedical engineering · 2024Article
- Assessment of the Aorto-Septal Angle Post-Thoracic Endovascular Aortic Repair through Segmentation and the Semi-Automatic Analysis of Cardiosynchronized Computed Tomography Angiography Images.Journal of cardiovascular development and disease · 2024Article
- Atypical Cardiac Anatomy Leading to Subvalvar Aortic Stenosis in a 19-Month-Old Boy With a Murmur.JACC. Case reports · 2024Article
- Subvalvular Aortic Stenosis: Learning From Human and Canine Clinical Research.Cardiology research · 2023Review
- Isolation and Characterization of Porcine Endocardial Endothelial Cells.Tissue engineering. Part C, Methods · 2023Article
- A Novel Mutation in theInternational journal of molecular sciences · 2023Article
- Hemodynamic Effects of Subaortic Stenosis on Blood Flow Characteristics of a Mechanical Heart Valve Based on OpenFOAM Simulation.Bioengineering (Basel, Switzerland) · 2023Article
- Significance of aortoseptal angle anomalies to left ventricular hemodynamics and subaortic stenosis: A numerical study.Computers in biology and medicine · 2022Article
- Co-occurrence of Anomalous Right Coronary Artery Origin and Subaortic Membrane in an Adult Male.Cureus · 2022Article
- Current state of the art in hypoplastic left heart syndrome.Frontiers in cardiovascular medicine · 2022Review
- Computational Assessment of Valvular Dysfunction in Discrete Subaortic Stenosis: A Parametric Study.Cardiovascular engineering and technology · 2021Article
- The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease.Frontiers in cardiovascular medicine · 2021Review
- Impact of Aortoseptal Angle Abnormalities and Discrete Subaortic Stenosis on Left-Ventricular Outflow Tract Hemodynamics: Preliminary Computational Assessment.Frontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Discrete subaortic stenosis (DSS) is a congenital heart disease that results in the formation of a fibro-membranous tissue, causing an increased pressure gradient in the left ventricular outflow tract (LVOT). While surgical resection of the membrane has shown some success in eliminating the obstruction, it poses significant risks associated with anesthesia, sternotomy, and heart bypass, and it remains associated with a high rate of recurrence. Although a genetic etiology had been initially proposed, the association between DSS and left ventricle (LV) geometrical abnormalities has provided more support to a hemodynamic etiology by which congenital or post-surgical LVOT geometric derangements could generate abnormal shear forces on the septal wall, triggering in turn a fibrotic response. Validating this hypothetical etiology and understanding the mechanobiological processes by which altered shear forces induce fibrosis in the LVOT are major knowledge gaps. This perspective paper describes the current state of knowledge of DSS, articulates the research needs to yield mechanistic insights into a significant pathologic process that is poorly understood, and proposes several strategies aimed at elucidating the potential mechanobiological synergies responsible for DSS pathogenesis. The proposed roadmap has the potential to improve DSS management by identifying early targets for prevention of the fibrotic lesion, and may also prove beneficial in other fibrotic cardiovascular diseases associated with altered flow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.