Evidence map›Paper›PMID 30320101›Full record

ArticleOcular oncology and pathology2018

Widespread Ocular Surface Squamous Neoplasia Treated with Topical Interferon Alpha-2b.

Hershel Patel, Lauren J Jeang, Ankit Shah, Edgar M Espana, Curtis E Margo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular oncology and pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hershel PatelDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Lauren J JeangDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Ankit ShahDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, Florida, USA.
Edgar M EspanaDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
Curtis E MargoDepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA.
University of South Florida · USFlorida College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo emphasize the importance of staging ocular surface squamous neoplasia when contemplating use of topical interferon alpha-2b alone. CASES: Two patients with 360 degrees of limbal involvement.

resultsTwo patients with in situ squamous cell carcinoma of the conjunctiva and clinical involvement of the entire limbus were treated with topical interferon alpha-2b. Thorough examination and multiple biopsies excluded invasive disease. The patients had complete response to therapy.

conclusionWidespread intraepithelial squamous neoplasia involving the entire limbus can be successfully treated with topical therapies. Biopsy plays a role in excluding invasive disease. Interferon alpha-2b is a preferable agent to start with because it is well tolerated. Since long-term risks of recurrence are unknown, appropriate monitoring is essential.

Indexed as

Conjunctival intraepithelial neoplasiaCytokine immunotherapyInterferon alpha-2bOcular surfaceOcular surface squamous neoplasia

Identifiers

PMID30320101
PMCPMC6167668
OpenAlexW2788423062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.