Evidence map›Paper›PMID 30319904›Full record

ArticleBiomedical optics express2018

High-resolution infrared imaging of biological samples with third-order sum-frequency generation microscopy.

Adam M Hanninen, Richard C Prince, Raul Ramos, Maksim V Plikus, Eric O Potma

Abstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Digital Histopathology by Infrared Spectroscopic Imaging.Annual review of analytical chemistry (Palo Alto, Calif.) · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Adam M HanninenDepartment of Astronomy and Physics, University of California, Irvine, CA 92697, USA.
Richard C PrinceDepartment of Biomedical Engineering, University of California, Irvine, CA 92697, USA.ORCID https://orcid.org/0000-0003-1199-9465
Raul RamosDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.
Maksim V PlikusDepartment of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.
Eric O PotmaDepartment of Chemistry, University of California, Irvine, CA 92697, USA.ORCID https://orcid.org/0000-0003-3916-6131

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI VENUGOPALAN, VASAN · 2012 to 2017
$7.0M
Induction of fat regeneration in skin wounds by hair follicle signalingR01AR067273 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PLIKUS, MAKSIM V · 2014 to 2018
$1.9M
Skin Defense by Dermal AdipocytesR01AR069653 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2016 to 2020
$1.9M
NIAMS NIH HHS R01 AR067273NIAMS NIH HHS R01 AR069653NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

We studied the use of vibrationally resonant, third-order sum-frequency generation (TSFG) for imaging of biological samples. We found that laser-scanning TSFG provides vibrationally sensitive imaging capabilities of lipid droplets and structures in sectioned tissue samples. Although the contrast is based on the infrared-activity of molecular modes, TSFG images exhibit a high lateral resolution of 0.5

Identifiers

PMID30319904
PMCPMC6179410

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.