ArticleBiomedical optics express2018
Quantification of stored red blood cell fluctuations by time-lapse holographic cell imaging.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- AI-driven dual-mode phase and label-free fluorescence imaging platform using a single-shot gabor hologram.Microsystems & nanoengineering · 2026Article
- AI-driven digital holographic microscopy for label-free quantitative cellular analysis: toward low-cost and field-deployable platforms.Biomedical optics express · 2026Review
- Label-Free Digital Holotomography Reveals Ibuprofen-Induced Morphological Changes to Red Blood Cells.ACS nanoscience Au · 2023Article
- COVID-19 screening with digital holographic microscopy using intra-patient probability functions of spatio-temporal bio-optical attributes.Biomedical optics express · 2022Article
- Biomechanical properties of native and cultured red blood cells-Interplay of shape, structure and biomechanics.Frontiers in physiology · 2022Article
- Article
- Deep learning-based cell identification and disease diagnosis using spatio-temporal cellular dynamics in compact digital holographic microscopy.Biomedical optics express · 2020Article
- Automated single cardiomyocyte characterization by nucleus extraction from dynamic holographic images using a fully convolutional neural network.Biomedical optics express · 2020Article
- Quantitative absorption imaging of red blood cells to determine physical and mechanical properties.RSC advances · 2020Article
- Quantitative analysis of three-dimensional morphology and membrane dynamics of red blood cells during temperature elevation.Scientific reports · 2019Article
- No-search focus prediction at the single cell level in digital holographic imaging with deep convolutional neural network.Biomedical optics express · 2019Article
- Automated quantification study of human cardiomyocyte synchronization using holographic imaging.Biomedical optics express · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We propose methods to quantitatively calculate the fluctuation rate of red blood cells with nanometric axial and millisecond temporal sensitivity at the single-cell level by using time-lapse holographic cell imaging. For this quantitative analysis, cell membrane fluctuations (CMFs) were measured for RBCs stored at different storage times. Measurements were taken over the whole membrane for both the ring and dimple sections separately. The measurements show that healthy RBCs that maintain their discocyte shape become stiffer with storage time. The correlation analysis demonstrates a significant negative correlation between CMFs and the sphericity coefficient, which characterizes the morphological type of erythrocyte. In addition, we show the correlation results between CMFs and other morphological properties such as projected surface area, surface area, mean corpuscular volume, and mean corpuscular hemoglobin.
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Registered trials
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