Evidence map›Paper›PMID 30319652›Full record

Trial reportFrontiers in immunology2018

Immune Stimulation Using a Gut Microbe-Based Immunotherapy Reduces Disease Pathology and Improves Barrier Function in Ulcerative Colitis.

Ho Pan Sham, Mark Bazett, Momir Bosiljcic, Hyungjun Yang, Beryl Luk, Hong T Law, Vijay Morampudi, Hong B Yu, Jim Pankovich, Simon Sutcliffe and 8 more

Registry-linked trialOpen access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05677113 (A Phase II Study of Perioperative QBECO Site Specific Immunomodulator), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05677113 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation

A Phase II Study of Perioperative QBECO Site Specific Immunomodulator (Qu Biologics®) in Patients With Metastatic Colorectal Adenocarcinoma Within the Liver Undergoing Resection

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2023 to 2031Enrolled115ConditionsColorectal Cancer, Liver MetastasesArmsQBECO, Placebo
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Frontiers in microbiology · 2025
    Article
  7. Review
  8. Frontiers in pharmacology · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Ho Pan ShamQu Biologics Inc., Vancouver, BC, Canada.
Mark BazettQu Biologics Inc., Vancouver, BC, Canada.
Momir BosiljcicQu Biologics Inc., Vancouver, BC, Canada.
Hyungjun YangDivision of Gastroenterology, Department of Pediatrics, BC Children's Hospital Research Institute (BCCHRI), University of British Columbia, Vancouver, BC, Canada.
Beryl LukQu Biologics Inc., Vancouver, BC, Canada.
Hong T LawQu Biologics Inc., Vancouver, BC, Canada.
Vijay MorampudiDivision of Gastroenterology, Department of Pediatrics, BC Children's Hospital Research Institute (BCCHRI), University of British Columbia, Vancouver, BC, Canada.
Hong B YuDivision of Gastroenterology, Department of Pediatrics, BC Children's Hospital Research Institute (BCCHRI), University of British Columbia, Vancouver, BC, Canada.
Jim PankovichQu Biologics Inc., Vancouver, BC, Canada.
Simon SutcliffeQu Biologics Inc., Vancouver, BC, Canada.
Brian BresslerDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
John K MarshallDepartment of Medicine and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada.
Richard N FedorakDivision of Gastroenterology, University of Alberta, Edmonton, AB, Canada.
Jenny ChenQu Biologics Inc., Vancouver, BC, Canada.
Michelle JonesQu Biologics Inc., Vancouver, BC, Canada.
Hal GunnQu Biologics Inc., Vancouver, BC, Canada.
Shirin KalyanQu Biologics Inc., Vancouver, BC, Canada.
Bruce A VallanceDivision of Gastroenterology, Department of Pediatrics, BC Children's Hospital Research Institute (BCCHRI), University of British Columbia, Vancouver, BC, Canada.
BC Children's Hospital · CAUniversity of British Columbia · CAMcMaster University · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAnimalsColitis, UlcerativeColonDextran SulfateDisease Models, AnimalEscherichia coliFemaleGastrointestinal MicrobiomeHumansImmunotherapyInjections, SubcutaneousIntestinal MucosaMaleMiceMice, Inbred C57BLDextran SulfateMuc2 protein, mouseMucin-2barrier functionimmunotherapyinflammationmicrobial therapymucosal immunityulcerative colitis

Identifiers

PMID30319652
PMCPMC6170651
OpenAlexW2891432515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.