Evidence map›Paper›PMID 30319636›Full record

ArticleFrontiers in immunology2018

Early Everolimus Initiation Fails to Counteract the Cytotoxic Response Mediated by CD8

Beatriz Díaz-Molina, Paula Diaz-Bulnes, Reyes Carvajal Palao, Maria José Bernardo, Ramón M Rodriguez, Viviana Corte-Iglesias, Cesar Moris de la Tassa, Jose Luis Lambert, Beatriz Suarez-Alvarez

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Immunosuppression Management in Heart Transplantation.Methodist DeBakey cardiovascular journal · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Beatriz Díaz-MolinaAdvanced Heart Failure and Transplant Service, Department of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Paula Diaz-BulnesTranslational Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.
Reyes Carvajal PalaoTranslational Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.
Maria José BernardoAdvanced Heart Failure and Transplant Service, Department of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Ramón M RodriguezTranslational Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.
Viviana Corte-IglesiasTranslational Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.
Cesar Moris de la TassaDepartment of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Jose Luis LambertAdvanced Heart Failure and Transplant Service, Department of Cardiology, Hospital Universitario Central de Asturias, Oviedo, Spain.
Beatriz Suarez-AlvarezTranslational Immunology Laboratory, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Hospital Universitario Central de Asturias, Oviedo, Spain.
Instituto de Investigación Sanitaria del Principado de Asturias · ESHospital Universitario Central de Asturias · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The positive long-term effects of conversion to everolimus (EVL) after heart transplantation (HT) have been evaluated in several studies. However, the timing of EVL initiation, the best way to combine it with other immunosuppressive treatments, and the impact of these combinations on the immune response are poorly understood aspects. Here, we analyzed the immune phenotype and function of HT patients (

Indexed as

AdolescentAdultAgedAllograftsCardiomyopathy, DilatedCD8-Positive T-LymphocytesEverolimusFemaleGraft RejectionHeartHeart TransplantationHumansImmunosuppressive AgentsKiller Cells, NaturalMaleMiddle AgedEverolimusImmunosuppressive AgentsMycophenolic AcidCD8+ T cellscytotoxicityDNA methylationeverolimusheart transplantationmTOR inhibitorsNK cells

Identifiers

PMID30319636
PMCPMC6168668
OpenAlexW2894398309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.