Evidence map›Paper›PMID 30319601›Full record

ReviewFrontiers in immunology2018

The Challenge of the Pathogenesis of Parkinson's Disease: Is Autoimmunity the Culprit?

Tianfang Jiang, Gen Li, Jun Xu, Shane Gao, Xu Chen

Erratum issuedOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
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  5. Review
  6. Article
  7. Article
  8. Observational
  9. Review
  10. Review
  11. The controversial effect of smoking and nicotine in SARS-CoV-2 infection.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Inflammatory Animal Models of Parkinson's Disease.Journal of Parkinson's disease · 2022
    Review
  17. Review
  18. Review
  19. Review
  20. Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Tianfang JiangDepartment of Neurology, Shanghai Eighth People's Hospital Affiliated to Jiang Su University, Shanghai, China.
Gen LiDepartment of Neurology & Institute of Neurology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jun XuEast Hospital, Tong Ji University School of Medicine, Shanghai, China.
Shane GaoEast Hospital, Tong Ji University School of Medicine, Shanghai, China.
Xu ChenDepartment of Neurology, Shanghai Eighth People's Hospital Affiliated to Jiang Su University, Shanghai, China.
Shanghai East Hospital · CNShanghai Eighth People Hospital · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of autoimmunity in Parkinson's disease (PD), as one of the most popular research subjects, has been intensively investigated in recent years. Although the ultimate cause of PD is unknown, one major area of interest remains identifying new therapeutic targets and options for patients suffering from PD. Herein, we present a comprehensive review of the impacts of autoimmunity in neurodegenerative diseases, especially PD, and we have composed a logical argument to substantiate that autoimmunity is actively involved in the pathogenesis of PD through several proteins, including α-synuclein, DJ-1, PINK1, and Parkin, as well as immune cells, such as dendritic cells, microglia, T cells, and B cells. Furthermore, a detailed analysis of the relevance of autoimmunity to the clinical symptoms of PD provides strong evidence for the close correlation of autoimmunity with PD. In addition, the previously identified relationships between other autoimmune diseases and PD help us to better understand the disease pattern, laying the foundation for new therapeutic solutions to PD. In summary, this review aims to integrate and present currently available data to clarify the pathogenesis of PD and discuss some controversial but innovative research perspectives on the involvement of autoimmunity in PD, as well as possible novel diagnostic methods and treatments based on autoimmunity targets.

Indexed as

alpha-SynucleinAnimalsAutoantigensAutoimmunityB-LymphocytesBrainDendritic CellsDisease Models, AnimalHumansMicrogliaMutationParkinson DiseaseProtein Deglycase DJ-1Protein KinasesPTEN-Induced Putative KinaseT-Lymphocytesalpha-SynucleinAutoantigensPARK7 protein, humanparkin proteinProtein Deglycase DJ-1Protein KinasesPTEN-Induced Putative KinaseSNCA protein, humanUbiquitin-Protein Ligasesautoimmune diseasesautoimmunityneuroimmunologyParkinson's diseaseα-synuclein

Identifiers

PMID30319601
PMCPMC6170625
OpenAlexW2892643460

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.