ReviewFrontiers in endocrinology2018
Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss.
Review in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of menopausal hormone formulations on pituitary-ovarian regulatory feedback.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Trial
- Neuropathology-based approach reveals novel Alzheimer's Disease genes and highlights female-specific pathways and causal links to disrupted lipid metabolism: insights into a vicious cycle.Acta neuropathologica communications · 2025Article
- Relationship between depression and sex steroid hormone among women with epilepsy.Frontiers in neuroscience · 2024Article
- Endocrine Dyscrasia in the Etiology and Therapy of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Review
- Sex, sepsis and the brain: defining the role of sexual dimorphism on neurocognitive outcomes after infection.Clinical science (London, England : 1979) · 2023Review
- High-amplitude network co-fluctuations linked to variation in hormone concentrations over the menstrual cycle.Network neuroscience (Cambridge, Mass.) · 2023Article
- Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment.Frontiers in endocrinology · 2022Review
- Investigation of common risk factors between polycystic ovary syndrome and Alzheimer's disease: a narrative review.Reproductive health · 2021Review
- Gonadotropins at Advanced Age - Perhaps They Are Not So Bad? Correlations Between Gonadotropins and Sarcopenia Indicators in Older Adults.Frontiers in endocrinology · 2021Article
- Luteinizing hormone and the aging brain.Vitamins and hormones · 2021Review
- Testosterone and the brain: from cognition to autism.Physiological research · 2020Review
- Estrogen improved the regeneration of axons after subcortical axon injury via regulation of PI3K/Akt/CDK5/Tau pathway.Brain and behavior · 2020Article
- Associations of pituitary-ovarian hormones and white matter hyperintensities in recently menopausal women using hormone therapy.Menopause (New York, N.Y.) · 2020Article
- The Role of Estrogen in Anxiety-Like Behavior and Memory of Middle-Aged Female Rats.Frontiers in endocrinology · 2020Article
- The association between hormones and antipsychotic use: a focus on postpartum and menopausal women.Therapeutic advances in psychopharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pervasive age-related dysfunction in hypothalamic-pituitary-gonadal (HPG) axis is associated with cognitive impairments in aging as well as pathogenesis of age-related neurodegenerative diseases such as the Alzheimer's disease (AD). As a major regulator of the HPG axis, the steroid hormone estrogen has been widely studied for its role in regulation of memory. Although estrogen modulates both cognition as well as cognition associated morphological components in a healthy state, the benefits of estrogen replacement therapy on cognition and disease seem to diminish with advancing age. Emerging data suggests an important role for luteinizing hormone (LH) in CNS function, which is another component of the HPG axis that becomes dysregulated during aging, particularly in menopause. The goal of this review is to highlight the current existing literature on LH and provide new insights on possible mechanisms of its action.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.