Evidence map›Paper›PMID 30319454›Full record

ArticleFrontiers in physiology2018

A Single Complex

Marjoleine F Broekema, Maarten P G Massink, Joep De Ligt, Edwin C A Stigter, Houshang Monajemi, Jeroen De Ridder, Boudewijn M T Burgering, Gijs W van Haaften, Eric Kalkhoven

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. The Role of theInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Marjoleine F BroekemaCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Maarten P G MassinkCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Joep De LigtCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Edwin C A StigterCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Houshang MonajemiInstitute of Metabolic Science, Academic Medical Center, Amsterdam, Netherlands.
Jeroen De RidderCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Boudewijn M T BurgeringCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Gijs W van HaaftenCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
Eric KalkhovenCenter for Molecular Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, Netherlands.
University Medical Center Utrecht · NLUtrecht University · NLAcademic Medical Center · NL

Funding

Wellcome Trust
6 · The paper itself

Abstract

Genetic lipodystrophies are a group of rare syndromes associated with major metabolic complications - including severe insulin resistance, type 2 diabetes mellitus, and hypertriglyceridemia - which are classified according to the distribution of adipose tissue. Lipodystrophies can be present at birth or develop during life and can range from local to partial and general. With at least 18 different genes implicated so far, definite diagnosis can be challenging due to clinical and genetic heterogeneity. In an adult female patient with clinical and metabolic features of partial lipodystrophy we identified via whole genome sequencing (WGS) a single complex

Indexed as

adipose tissueAGPAT2lipodystrophymetabolic complicationstriacylglycerol synthesiswhole genome sequencing

Identifiers

PMID30319454
PMCPMC6168662
OpenAlexW2893644295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.