Evidence map›Paper›PMID 30319428›Full record

ArticleFrontiers in pharmacology2018

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy.

Senthilkumar Kalimuthu, Prakash Gangadaran, Ramya Lakshmi Rajendran, Liya Zhu, Ji Min Oh, Ho Won Lee, Arunnehru Gopal, Se Hwan Baek, Shin Young Jeong, Sang-Woo Lee and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 1 pooled it
8.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 1 synthesis or guideline pooled it, 257 citations in OpenAlex.

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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Senthilkumar KalimuthuDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Prakash GangadaranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Ramya Lakshmi RajendranDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Liya ZhuDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Ji Min OhDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Ho Won LeeDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Arunnehru GopalDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Se Hwan BaekDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Shin Young JeongDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sang-Woo LeeDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jaetae LeeDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Byeong-Cheol AhnDepartment of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Kyungpook National University · KRKyungpook National University Hospital · KR

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI MICHAEL R GARRETT · 2012 to 2026
$60.2M
NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Exosomes derived from mesenchymal stem cells (MSCs) have been evaluated for their potential to be used as drug delivery vehicles. Synthetically personalized exosome mimetics (EMs) could be the alternative vesicles for drug delivery. In this study, we aimed to isolate EMs from human MSCs. Cells were mixed with paclitaxel (PTX) and PTX-loaded EMs (PTX-MSC-EMs) were isolated and evaluated for their anticancer effects against breast cancer. EMs were isolated from human bone marrow-derived MSCs. MSCs (4 × 10

Indexed as

breast cancerexosome mimeticMDA-MB-231MSCpaclitaxel

Identifiers

PMID30319428
PMCPMC6168623
OpenAlexW2891582149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.