Evidence map›Paper›PMID 30319396›Full record

ArticleFrontiers in aging neuroscience2018

Radiomic Features of Hippocampal Subregions in Alzheimer's Disease and Amnestic Mild Cognitive Impairment.

Feng Feng, Pan Wang, Kun Zhao, Bo Zhou, Hongxiang Yao, Qingqing Meng, Lei Wang, Zengqiang Zhang, Yanhui Ding, Luning Wang and 3 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Hippocampal texture asymmetry features onFrontiers in immunology · 2026
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  17. Beyond Macrostructure: Is There a Role for Radiomics Analysis in Neuroimaging ?Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Feng FengDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Pan WangDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Kun ZhaoBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Bo ZhouDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Hongxiang YaoDepartment of Radiology, Chinese PLA General Hospital, Beijing, China.
Qingqing MengDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Lei WangDepartment of Neurology, The General Hospital of the PLA Rocket Force, Beijing, China.
Zengqiang ZhangDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Yanhui DingSchool of Information Science and Engineering, Shandong Normal University, Jinan, China.
Luning WangDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Ningyu AnDepartment of Radiology, Chinese PLA General Hospital, Beijing, China.
Xi ZhangDepartment of Neurology, Nanlou Division, Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Yong LiuBrainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by progressive dementia, especially in episodic memory, and amnestic mild cognitive impairment (aMCI) is associated with a high risk of developing AD. Hippocampal atrophy/shape changes are believed to be the most robust magnetic resonance imaging (MRI) markers for AD and aMCI. Radiomics, a method of texture analysis, can quantitatively examine a large set of features and has previously been successfully applied to evaluate imaging biomarkers for AD. To test whether radiomic features in the hippocampus can be employed for early classification of AD and aMCI, 1692 features from the caudal and head parts of the bilateral hippocampus were extracted from 38 AD patients, 33 aMCI patients and 45 normal controls (NCs). One way analysis of variance (ANOVA) showed that 111 features exhibited statistically significant group differences (

Indexed as

alzheimer’s diseaseamnestic mild cognitive impairmenthippocampal subregionsradiomic featuressupport vector machine

Identifiers

PMID30319396
PMCPMC6167420

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.