Evidence map›Paper›PMID 30319361›Full record

ArticleFrontiers in cellular neuroscience2018

Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats.

Shenandoah Robinson, Fatu S Conteh, Akosua Y Oppong, Tracylyn R Yellowhair, Jessie C Newville, Nagat El Demerdash, Christine L Shrock, Jessie R Maxwell, Stephen Jett, Frances J Northington and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pathophysiologic mechanisms and strategies for the treatment of post-hemorrhagic hydrocephalus of prematurity.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Pooled it
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  11. Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats.Journal of visualized experiments : JoVE · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shenandoah RobinsonDivision of Pediatric Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Fatu S ContehDivision of Pediatric Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Akosua Y OppongDivision of Pediatric Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Tracylyn R YellowhairDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Jessie C NewvilleDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Nagat El DemerdashDivision of Pediatric Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Christine L ShrockDivision of Pediatric Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Jessie R MaxwellDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Stephen JettDepartment of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Frances J NorthingtonDivision of Neonatology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Lauren L JantzieDepartment of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
University of New Mexico · USJohns Hopkins University · USJohns Hopkins Medicine · US

Funding

Purchase of a High Gradient Strength 7T 30 cm bore Magnetic Resonance Imaging ScannerS10OD021598 · OD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SELWYN, REED · 2016 to 2016
$1.8M
NIH HHS S10 OD021598
6 · The paper itself

Abstract

Posthemorrhagic hydrocephalus of prematurity (PHHP) remains a global challenge. Early preterm infants (<32 weeks gestation), particularly those exposed to chorioamnionitis (CAM), are prone to intraventricular hemorrhage (IVH) and PHHP. We established an age-appropriate, preclinical model of PHHP with progressive macrocephaly and ventriculomegaly to test whether non-surgical neonatal treatment could modulate PHHP. We combined prenatal CAM and postnatal day 1 (P1, equivalent to 30 weeks human gestation) IVH in rats, and administered systemic erythropoietin (EPO) plus melatonin (MLT), or vehicle, from P2 to P10. CAM-IVH rats developed progressive macrocephaly through P21. Macrocephaly was accompanied by ventriculomegaly at P5 (histology), and P21 (

Indexed as

cerebrospinal fluidchorioamnionitisciliadiffusion tensor imaging (DTI)intraventricular hemorrhage (IVH)neurorepairpretermventriculomegaly

Identifiers

PMID30319361
PMCPMC6167494
OpenAlexW2893025902

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.