ArticleFrontiers in neuroscience2018
A Process for Digitizing and Simulating Biologically Realistic Oligocellular Networks Demonstrated for the Neuro-Glio-Vascular Ensemble.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Ultrastructure of astrocytes using volume electron microscopy: A scoping review.The Journal of physiology · 2026Article
- Elucidating reaction dynamics in a model of human brain energy metabolism.PLoS computational biology · 2025Article
- Synthesis of geometrically realistic and watertight neuronal ultrastructure manifolds for in silico modeling.Briefings in bioinformatics · 2024Article
- Regulated exocytosis from astrocytes: a matter of vesicles?Frontiers in neuroscience · 2024Article
- CellRemorph: A Toolkit for Transforming, Selecting, and Slicing 3D Cell Structures on the Road to Morphologically Detailed Astrocyte Simulations.Neuroinformatics · 2023Article
- Ultraliser: a framework for creating multiscale, high-fidelity and geometrically realistic 3D models for in silico neuroscience.Briefings in bioinformatics · 2023Article
- l-Lactate: Food for Thoughts, Memory and Behavior.Metabolites · 2021Review
- Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations.Bioinformatics (Oxford, England) · 2021Article
- Augmented Reality in Medical Practice: From Spine Surgery to Remote Assistance.Frontiers in surgery · 2021Article
- Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis.Bioinformatics (Oxford, England) · 2020Article
- Energy-efficient information transfer at thalamocortical synapses.PLoS computational biology · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
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Abstract
One will not understand the brain without an integrated exploration of structure and function, these attributes being two sides of the same coin: together they form the currency of biological computation. Accordingly, biologically realistic models require the re-creation of the architecture of the cellular components in which biochemical reactions are contained. We describe here a process of reconstructing a functional oligocellular assembly that is responsible for energy supply management in the brain and creating a computational model of the associated biochemical and biophysical processes. The reactions that underwrite thought are both constrained by and take advantage of brain morphologies pertaining to neurons, astrocytes and the blood vessels that deliver oxygen, glucose and other nutrients. Each component of this neuro-glio-vasculature ensemble (NGV) carries-out delegated tasks, as the dynamics of this system provide for each cell-type its own energy requirements while including mechanisms that allow cooperative energy transfers. Our process for recreating the ultrastructure of cellular components and modeling the reactions that describe energy flow uses an amalgam of state-of the-art techniques, including digital reconstructions of electron micrographs, advanced data analysis tools, computational simulations and
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