Reduction of Angularly-Varying-Data Truncation in C-Arm CBCT Imaging.

C-arm cone-beam computed tomography (CBCT) has been used increasingly as an imaging tool for yielding 3D anatomical information about the subjects in surgical and interventional procedures. In the clinical applications, the limited field-of-view (FOV) of C-arm CBCT can lead to significant data truncation, resulting in image artifacts that can obscure low contrast tumor embedded within soft-tissue background, thus limiting the utility of C-arm CBCT. The truncation issue can become serious as most of the surgical and interventional procedures would involve devices and tubes that are placed outside the FOV of C-arm CBCT and thus can engender angularly-varying-data truncation. Existing methods may not be adequately applicable to dealing with the angularly-varying truncation. In this work, we seek to reduce truncation artifacts by tailoring optimization-based reconstruction directly from truncated data, without performing pre-reconstruction data compensation, collected from physical phantoms and human subjects. The reconstruction problem is formulated as a constrained optimization program in which a data-derivative-ℓ