Observational studyInternational journal of chronic obstructive pulmonary disease
Women manifest more severe COPD symptoms across the life course.
Observational study in International journal of chronic obstructive pulmonary disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Combined Model-Based Meta-Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials.CPT: pharmacometrics & systems pharmacology · 2026Pooled it
- The prevalence of metabolic syndrome in chronic obstructive pulmonary disease: A systematic review and meta-analysis.Chronic respiratory diseasePooled it
- Multi parameter respiratory training for pulmonary rehabilitation in AECOPD a randomized controlled trial.Scientific reports · 2026Trial
- Research frontiers and emerging trends in sex and gender differences in chronic obstructive pulmonary disease: a bibliometric analysis.Journal of thoracic disease · 2026Article
- Sex Differences and Survival Among COPD Patients in France: The Palomb Cohort.International journal of chronic obstructive pulmonary disease · 2026Observational
- Social determinants of health in clinical trials examining long-term oral antibiotics in COPD: a systematic review.ERJ open research · 2026Review
- An Examination of Sex Differences and Cigarette Smoking as Predictors of COPD Prevalence and Incidence in Older US Adults.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Article
- Exploring the Link Between Social and Economic Instability and COPD: A Cross-Sectional Analysis of the 2022 BRFSS.International journal of environmental research and public health · 2025Article
- Association between oral microbiome diversity and chronic obstructive pulmonary disease in the US population.Journal of translational medicine · 2025Article
- Gender, tobacco and chronic obstructive pulmonary disease: analysis of the 2020 National Health Interview Survey.BMJ open respiratory research · 2025Article
- Hospitalization Predictors in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Post Hoc Study of a Multicentric Retrospective Analysis.Journal of clinical medicine · 2025Article
- Sex Differences in Chronic Obstructive Pulmonary Disease: Implications for Pathogenesis, Diagnosis, and Treatment.International journal of molecular sciences · 2025Review
- Association of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) with COPD prevalence and all-cause mortality: a population-based study based on NHANES 2007-2016.Frontiers in medicine · 2025Article
- COPD in females- Seeing through the smoke.Lung India : official organ of Indian Chest Society · 2025Article
- Clinical features and prognostic risk factors of different sex with acute exacerbations of chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Reprint of: Smoking and pulmonary health in women: A narrative review and behavioral health perspective.Preventive medicine · 2024Review
- Differential effects of environmental exposures on clinically relevant endophenotypes between sexes.Scientific reports · 2024Article
- Symptom burden and its associations with clinical characteristics in patients with COPD: a clustering approach.ERJ open research · 2024Article
- Consideration of sex as a biological variable in diabetes research across twenty years.Biology of sex differences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundPrevious studies suggest that gender differences exist in COPD diagnosis and symptoms; these differences may be more pronounced in younger adults. Our objective was to explore age-associated gender differences across a range of COPD severities. MATERIALS AND
methodsA total of 4,484 current and former smokers with COPD from the Genetic Epidemiology of COPD cohort were investigated using regression modeling to explore the association between gender, age, disease severity, and the contributing elements of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification system (symptoms, exacerbation risk, airflow limitation).
resultsThe age-gender interaction was observed across multiple age categories. Compared to men with COPD, younger women with COPD had a greater likelihood of more severe dyspnea, airflow limitation, greater risk for exacerbations, and categorization in GOLD groups B and D. These differences were less pronounced in older women with COPD. However, older women remained more likely to experience severe dyspnea and to manifest more severe COPD (B vs A) than older men, despite lower pack-years of smoking.
conclusionThese data demonstrate the significant symptom burden of COPD in women, especially younger women. More research is needed to understand the pathogenesis of increased severity of COPD in women and to develop gender-targeted clinical assessment and management approaches to improve outcomes for women and men with COPD at all ages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.