ArticleThe Indian journal of radiology & imaging
Conventional and advanced brain MR imaging in patients with sickle cell anemia.
Article in The Indian journal of radiology & imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.BMC medicine · 2020Pooled it
- Magnetic Resonance Imaging of Musculoskeletal Manifestations in Sickle Cell Disease.Journal of clinical medicine · 2025Article
- Review
- White-matter abnormalities and cognitive dysfunction are linked to astrocyte activation in sickle mice.PNAS nexus · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSickle cell disease (SCD) is an autosomal recessive hemolytic disorder; its cerebrovascular complications include silent cerebral ischemia, infarct, and brain atrophy. Conventional magnetic resonance imaging (MRI) often underestimates the extent of injury. Diffusion tensor imaging (DTI) can demonstrate and quantify microstructural brain changes in SCD cases having normal routine MRI.
objectiveTo identify various neurological abnormalities in asymptomatic sickle cell patients using routine MRI and to evaluate the microstructure of various regions of the brain using DTI. MATERIALS AND
methodsA prospective, randomized case-control study was conducted over a period of 2 years. A total of 58 cases of SCD and 56 age- and sex-matched controls were included. Routine MRI and DTI were performed in both the groups following a standard protocol. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were calculated in certain pre-defined regions. Primary data were analyzed using MS excel version 17. Analysis of variance test was performed and statistical significance was set at
resultsThirty regions of interest with 60 variables were included in the final analysis. Patients with SCD showed statistically significant reduced FA values, increased ADC values, or both, clustered in several brain areas, including pons, cerebral peduncle, corpus callosum, frontal, temporal, parietal white matter, centrum semiovale, periventricular areas, basal ganglia, and left thalamus (
conclusionDTI is a promising method for characterizing microstructural changes, when conventional MRI is normal.
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