Evidence map›Paper›PMID 30319177›Full record

ArticleSensors and actuators. B, Chemical2018

Fluorescent Probes Based on π-Conjugation Modulation between Hemicyanine and Coumarin Moieties for Ratiometric Detection of pH Changes in Live Cells with Visible and Near-infrared Channels.

Shuai Xia, Jianbo Wang, Jianheng Bi, Xiao Wang, Mingxi Fang, Tyler Phillips, Aslan May, Nathan Conner, Marina Tanasova, Fen-Tair Luo and 1 more

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Shuai XiaDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Jianbo WangDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Jianheng BiDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Xiao WangDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Mingxi FangDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Tyler PhillipsDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Aslan MayDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Nathan ConnerDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Marina TanasovaDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Fen-Tair LuoInstitute of Chemistry, Academia Sinica, Taipei, Taiwan 11529, Republic of China.
Haiying LiuDepartment of Chemistry, Michigan Technological University, Houghton, MI 49931.
Michigan Technological University · USInstitute of Chemistry, Academia Sinica · TW

Funding

Ratiometric Near-infrared Fluorescent Probes for Lysosomal pH in Living CellsR15GM114751 · NIGMS · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI LIU, HAIYING · 2015 to 2019
$798k
NIGMS NIH HHS R15 GM114751
6 · The paper itself

Abstract

We report two ratiometric fluorescent probes based on π-conjugation modulation between coumarin and hemicyanine moieties for sensitive ratiometric detection of pH alterations in live cells by monitoring visible and near-infrared fluorescence changes. In a π-conjugation modulation strategy, a coumarin dye was conjugated to a near-infrared hemicyanine dye via a vinyl connection while lysosome-targeting morpholine ligand and o-phenylenediamine residue were introduced to the hemicyanine dye to form closed spirolactam ring structures in probes

Indexed as

Fluorescent probelive cellsnear-infrared emissionpHRatiometric imaging

Identifiers

PMID30319177
PMCPMC6178979
OpenAlexW2789949130

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.