SynthesisThe Journal of international medical research2018
Effectiveness and weakness of local infiltration analgesia in total knee arthroplasty: a systematic review.
Synthesis in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Combined intrathecal fentanyl and morphine for postoperative analgesia after total knee arthroplasty: a randomised controlled trial.BMC anesthesiology · 2026Trial
- Continuous local infiltration analgesia is equal to femoral and sciatic nerve block for total knee arthroplasty.Archives of orthopaedic and trauma surgery · 2025Trial
- Femoral nerve blockade versus local infiltration analgesia for primary knee arthroplasty. Randomised controlled trial.Anaesthesiology intensive therapy · 2022Trial
- Multimodal analgesia protocol for pain management after total knee arthroplasty: comparison of three different regional analgesic techniques.Journal of musculoskeletal & neuronal interactions · 2021Trial
- Continuous Adductor Canal Block used for postoperative pain relief after medial Unicondylar Knee Arthroplasty: a randomized, double-blind, placebo-controlled trial.BMC anesthesiology · 2019Trial
- Article
- Comparative Efficacy of Periarticular Fentanyl versus Ketorolac for Postoperative Pain in Total Hip Arthroplasty: A Randomized Controlled Trial.Journal of orthopaedic case reports · 2025Article
- A Collaborative Multimodal Pain Management Pathway Reduces Opiate Consumption After Total Hip and Knee Arthroplasty.Arthroplasty today · 2025Article
- Effects of Periarticular Multimodal Drug Injection on Pain Control, Early Mobilization, and Length of Hospital Stay in Patients Undergoing Total Knee Arthroplasty.Life (Basel, Switzerland) · 2024Article
- Key Elements of Enhanced Recovery after Total Joint Arthroplasty: A Reanalysis of the Enhanced Recovery after Surgery Guidelines.Orthopaedic surgery · 2023Review
- Review
- Postoperative Pain Management in Total Knee Arthroplasty.Orthopaedic surgery · 2019Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local infiltration analgesia has been widely used for pain relief in patients undergoing total knee arthroplasty. However, the effectiveness and major weakness of this technique have not been clarified; therefore, improvements in the technique have been limited. We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials and conducted a meta-analysis of randomized controlled trials comparing local infiltration analgesia with placebo infiltration in patients undergoing total knee arthroplasty. Fourteen trials involving 1305 knees were eligible. The results showed that local infiltration analgesia significantly reduced early perioperative pain and total narcotic consumption. However, postoperative functional outcomes were not significantly different between local infiltration analgesia and placebo. The pain-relieving effect of local infiltration analgesia was found to be strong but short in duration. In the future, modified delivery methods and formulas with longer durations of action and analgesia may provide a better environment for patients and therefore improve their function outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.