ArticleChembiochem : a European journal of chemical biology2019
Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.
Article in Chembiochem : a European journal of chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Biocatalytic Regioselective C-Formylation of Resorcinol Derivatives.Angewandte Chemie (International ed. in English) · 2026Article
- Evolutionary repurposing of a metabolic thiolase complex enables antibiotic biosynthesis.Nature communications · 2026Article
- Interspecies signaling modulates the biosynthesis of antimicrobial secondary metabolites related to biological control activities ofMicrobiology spectrum · 2025Article
- Computational Study of the Fries Rearrangement Catalyzed by Acyltransferase from Pseudomonas protegens.ChemistryOpen · 2024Article
- Biocatalytic Friedel-Crafts Reactions.ChemCatChem · 2022Review
- Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules.The Journal of biological chemistry · 2022Article
- Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis.eLife · 2022Article
- Article
- Pyoluteorin and 2,4-diacetylphloroglucinol are major contributors toFrontiers in microbiology · 2022Article
- Phloroglucinol Derivatives in Plant-BeneficialMetabolites · 2021Review
- Power of Biocatalysis for Organic Synthesis.ACS central science · 2021Review
- Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46.The Journal of antibiotics · 2020Article
- CariogenicACS infectious diseases · 2020Article
- Crystal structure of the translation recovery factor Trf from Sulfolobus solfataricus.FEBS open bio · 2020Article
- Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors.ACS catalysis · 2020Article
- Mechanism of Biocatalytic Friedel-Crafts Acylation by Acyltransferase fromACS catalysis · 2020Article
- The steroid side-chain-cleaving aldolase Ltp2-ChsH2The Journal of biological chemistry · 2019Article
- Structure and Catalytic Mechanism of a Bacterial Friedel-Crafts Acylase.Chembiochem : a European journal of chemical biology · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
C-C bond-forming reactions are key transformations for setting up the carbon frameworks of organic compounds. In this context, Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, which are common motifs in many fine chemicals and natural products. A bacterial multicomponent acyltransferase from Pseudomonas protegens (PpATase) catalyzes such Friedel-Crafts C-acylation of phenolic substrates in aqueous solution, reaching up to >99 % conversion without the need for CoA-activated reagents. We determined X-ray crystal structures of the native and ligand-bound complexes. This multimeric enzyme consists of three subunits: PhlA, PhlB, and PhlC, arranged in a Phl(A
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