ArticleHuman brain mapping2019
Cluster failure revisited: Impact of first level design and physiological noise on cluster false positive rates.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional Magnetic Resonance Imaging of Post-Traumatic Headache: A Systematic Review.Current pain and headache reports · 2025Pooled it
- The roles of emotional responding and regulation in adolescent friendship stability: A multimethod functional magnetic resonance imaging study.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Interactions between sensory-biased and supramodal working memory networks in the human cerebral cortex.Communications biology · 2026Article
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- Learning to Program "Recycles" Preexisting Frontoparietal Population Codes of Logical Algorithms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Common and distinct BOLD correlates of Simon and flanker conflicts which can(not) be reduced to time-on-task effects.Human brain mapping · 2024Article
- Denoising task-related fMRI: Balancing noise reduction against signal loss.Human brain mapping · 2023Article
- Hippocampal Resting State Functional Connectivity Associated with Physical Activity in Periadolescent Children.Brain sciences · 2023Article
- Reading Braille by Touch Recruits Posterior Parietal Cortex.Journal of cognitive neuroscience · 2023Article
- Childhood trauma, earlier pubertal timing, and psychopathology in adolescence: The role of corticolimbic development.Developmental cognitive neuroscience · 2023Article
- Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.Pain research & management · 2023Article
- Lateral prefrontal cortex is a hub for music production from structural rules to movements.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Alcohol- and non-alcohol-related interference: An fMRI study of treatment-seeking adults with alcohol use disorder.Drug and alcohol dependence · 2022Article
- An integrated cluster-wise significance measure for fMRI analysis.Human brain mapping · 2022Article
- State or trait: the neurobiology of anorexia nervosa - contributions of a functional magnetic resonance imaging study.Journal of eating disorders · 2022Article
- Neural function underlying reward expectancy and attainment in adolescents with diverse psychiatric symptoms.NeuroImage. Clinical · 2022Article
- Bayes estimate of primary threshold in clusterwise functional magnetic resonance imaging inferences.Statistics in medicine · 2021Article
- Resting-state functional connectivity of the human hippocampus in periadolescent children: Associations with age and memory performance.Human brain mapping · 2021Article
- Bridging the Brain and Data Sciences.Big data · 2021Article
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3 authors.
Funding
Abstract
Methodological research rarely generates a broad interest, yet our work on the validity of cluster inference methods for functional magnetic resonance imaging (fMRI) created intense discussion on both the minutia of our approach and its implications for the discipline. In the present work, we take on various critiques of our work and further explore the limitations of our original work. We address issues about the particular event-related designs we used, considering multiple event types and randomization of events between subjects. We consider the lack of validity found with one-sample permutation (sign flipping) tests, investigating a number of approaches to improve the false positive control of this widely used procedure. We found that the combination of a two-sided test and cleaning the data using ICA FIX resulted in nominal false positive rates for all data sets, meaning that data cleaning is not only important for resting state fMRI, but also for task fMRI. Finally, we discuss the implications of our work on the fMRI literature as a whole, estimating that at least 10% of the fMRI studies have used the most problematic cluster inference method (p = .01 cluster defining threshold), and how individual studies can be interpreted in light of our findings. These additional results underscore our original conclusions, on the importance of data sharing and thorough evaluation of statistical methods on realistic null data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.