ArticleJournal of medical virology2019
Evidence for an unknown agent antigenically related to the hepatitis E virus in dairy cows in the United States.
Article in Journal of medical virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Absence of hepatitis E virus RNA in bovines from Portugal.Veterinary research communications · 2025Article
- Rat hepatitis E virusEmerging microbes & infections · 2024Article
- Hepatitis E Virus in Domestic Ruminants and Virus Excretion in Milk-A Potential Source of Zoonotic HEV Infection.Viruses · 2024Review
- Amino acid pattern reveals multi-functionality of ORF3 protein from HEV.Bioinformation · 2024Article
- Hepatitis E Virus in Livestock-Update on Its Epidemiology and Risk of Infection to Humans.Animals : an open access journal from MDPI · 2023Review
- Article
- A Systematic Review and Meta-Analysis on Hepatitis E Virus Detection in Farmed Ruminants.Pathogens (Basel, Switzerland) · 2023Review
- Intrinsic disorder in the open reading frame 2 of hepatitis E virus: a protein with multiple functions beyond viral capsid.Journal, genetic engineering & biotechnology · 2023Article
- First serological and molecular investigation of hepatitis E virus infection in dromedary camels in Algeria.Frontiers in veterinary science · 2023Article
- Hepatitis E as a Zoonosis.Advances in experimental medicine and biology · 2023Article
- Current Knowledge of Hepatitis E Virus (HEV) Epidemiology in Ruminants.Pathogens (Basel, Switzerland) · 2022Review
- Hepatitis E virus in the endangered Iberian lynx (Lynx pardinus).Transboundary and emerging diseases · 2022Article
- Hepatitis E virus genotype 3 in bovine livers slaughtered in the state of Rio Grande do Sul, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Prevalence of hepatitis E virus antibodies in cattle in Burkina Faso associated with swine mixed farming.Journal of veterinary science · 2022Article
- Revisiting the Mongolian Gerbil Model for Hepatitis E Virus by Reverse Genetics.Microbiology spectrum · 2022Article
- Role of "dual-personality" fragments in HEV adaptation-analysis of Y-domain region.Journal, genetic engineering & biotechnology · 2021Article
- The Foodborne Transmission of Hepatitis E Virus to Humans.Food and environmental virology · 2021Review
- Hepatitis E Virus Infection and Butchers: A Case-Control Seroprevalence Study.Gastroenterology research · 2021Article
- Prevalence of anti-hepatitis E virus antibodies in domestic animal from three representative provinces of Burkina Faso.Veterinary and animal science · 2019Article
- Genetic Variability and Evolution of Hepatitis E Virus.Viruses · 2019Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
Genotypes 3 and 4 hepatitis E virus (HEV) strains within the species Orthohepevirus A in the family Hepeviridae are zoonotic. Recently, a genotype 4 HEV was reportedly detected in fecal samples of cows, although independent confirmation is lacking. In this study, we first tested serum samples from 983 cows in different regions in the United States for the presence of immunoglobulin G (IgG) anti-HEV and found that 20.4% of cows were seropositive. The highest seroprevalence rate (68.4%) was from a herd in Georgia. In an attempt to genetically identify HEV in cattle, a prospective study was conducted in a known seropositive dairy herd by monitoring 10 newborn calves from birth to 6 months of age for evidence of HEV infection. At least 3 of the 10 calves seroconverted to IgG anti-HEV, and importantly the antibodies presented neutralized genotype 3 human HEV, thus, indicating the specificity of IgG anti-HEV in the cattle. However, our extensive attempts to identify HEV-related sequences in cattle using broad-spectrum reverse transcription-polymerase chain reaction assays and MiSeq deep-sequencing technology failed. The results suggest the existence of an agent antigenically related to HEV in cattle, although, contrary to published reports, we showed that the IgG recognizing HEV in cattle was not caused by HEV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.