ArticleEuropean journal of clinical pharmacology2019
Decrease in loop diuretic treatment from 2005 to 2014 in Swedish real-life patients with chronic heart failure.
Article in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Prevalence of heart failure and trends in its pharmacological treatment between 2000 and 2017 among very old people.BMC geriatrics · 2024Article
- Motives, frequency, predictors and outcomes of MRA discontinuation in a real-world heart failure population.Open heart · 2022Article
- Temporal trends of a vasopressin VESC heart failure · 2021Article
- Cardiovascular drug use among people with cognitive impairment living in nursing homes in northern Sweden.European journal of clinical pharmacology · 2020Article
- Use of diuretics in shock: Temporal trends and clinical impacts in a propensity-matched cohort study.PloS one · 2020Article
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Authors and funding
4 authors.
Funding
Abstract
purposeLoop diuretics are recommended to treat congestive symptoms in patients with heart failure. However, observational studies have indicated that loop diuretic treatment in heart failure is associated with increased mortality. Therefore, loop diuretic discontinuation or dose reduction, when clinically possible, is recommended. Our aim was to study nationwide temporal trends in loop diuretic treatment from 2005 to 2014 in real-life patients with chronic heart failure.
methodsData from the nationwide Swedish National Patient, Prescribed Drug and Cause of Death Registers were linked. The annual proportions of patients with chronic heart failure treated with loop diuretics from 2005 to 2014 were calculated. In addition, the annual median loop diuretic doses (DDD) in patients with chronic heart failure treated with loop diuretics from 2005 to 2014 were calculated.
resultsThe proportion of real-life patients with chronic heart failure treated with loop diuretics decreased from 73.2% in 2005 to 65.7% in 2014 (p for trend < 0.001). The median loop diuretic DDD in real-life patients with chronic heart failure decreased from 2.13 (IQR 1.09-2.77) in 2005 to 1.63 (IQR 1.09-2.25) in 2014 (p = 0.001 for trend).
conclusionsLoop diuretic treatment decreased from 2005 to 2014 in real-life patients with chronic heart failure. The prognostic impact of changes in loop diuretic treatment in patients with heart failure remains unclear.
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